Dimethyl 2-oxoglutarate (Synonyms: Dimethyl α-ketoglutarate)

Cat. No.: HY-44134 Purity: 97.02%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dimethyl 2-oxoglutarate serves as a crucial intermediate in the Krebs cycle and an essential nitrogen carrier in metabolic pathways during biological processes. The electrochemical behavior of Dimethyl 2-oxoglutarate can be investigated using cyclic voltammetry, square wave voltammetry, and differential pulse voltammetry with a glassy carbon electrode.

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Dimethyl 2-oxoglutarate Chemical Structure

CAS No. : 13192-04-6

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5 g	USD 30	In-stock	Estimated Time of Arrival: December 31
10 g	USD 50	In-stock	Estimated Time of Arrival: December 31
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Purity & Documentation
References
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Description

IC₅₀ & Target

Microbial Metabolite

Molecular Weight

174.15

Formula

C₇H₁₀O₅

CAS No.

13192-04-6

Appearance

Liquid (Density: 1.175±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(OC)C(CCC(OC)=O)=O

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (574.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (574.22 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.7422 mL	28.7109 mL	57.4218 mL
5 mM	1.1484 mL	5.7422 mL	11.4844 mL
10 mM	0.5742 mL	2.8711 mL	5.7422 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (574.22 mM); Clear solution; Need ultrasonic
Protocol 2

Add each solvent one by one: 0.5% CMC/saline water
Solubility: ≥ 50 mg/mL (287.11 mM); Clear solution
Protocol 3

Add each solvent one by one: 50% PEG300 50% PBS
Solubility: ≥ 50 mg/mL (287.11 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 97.02%

Select Batch:

Data Sheet (269 KB) SDS (394 KB)

COA (244 KB) HNMR (230 KB) MS (70 KB) GC (175 KB)

Handling Instructions (2659 KB)

References

[1]. Shah A, et al. Electrochemical behaviour of dimethyl-2-oxoglutarate on glassy carbon electrode[J]. Bioelectrochemistry, 2010, 77(2): 145-150. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.7422 mL	28.7109 mL	57.4218 mL	143.5544 mL
	5 mM	1.1484 mL	5.7422 mL	11.4844 mL	28.7109 mL
	10 mM	0.5742 mL	2.8711 mL	5.7422 mL	14.3554 mL
	15 mM	0.3828 mL	1.9141 mL	3.8281 mL	9.5703 mL
	20 mM	0.2871 mL	1.4355 mL	2.8711 mL	7.1777 mL
	25 mM	0.2297 mL	1.1484 mL	2.2969 mL	5.7422 mL
	30 mM	0.1914 mL	0.9570 mL	1.9141 mL	4.7851 mL
	40 mM	0.1436 mL	0.7178 mL	1.4355 mL	3.5889 mL
	50 mM	0.1148 mL	0.5742 mL	1.1484 mL	2.8711 mL
	60 mM	0.0957 mL	0.4785 mL	0.9570 mL	2.3926 mL
	80 mM	0.0718 mL	0.3589 mL	0.7178 mL	1.7944 mL
	100 mM	0.0574 mL	0.2871 mL	0.5742 mL	1.4355 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Dimethyl 2-oxoglutarate Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl 2-oxoglutarate13192-04-6Dimethyl α-ketoglutarateEndogenous Metaboliteelectrochemical behaviorKrebs cycleInhibitorinhibitorinhibit

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