DMT-dC(bz) Phosphoramidite

Name: DMT-dC(bz) Phosphoramidite
Brand: MedChemExpress
SKU: HY-W008849
Rating: 4.5 (1 reviews)

Cat. No.: HY-W008849 Purity: 98.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DMT-dC(bz) Phosphoramidite is typically used in the synthesis of DNA.

For research use only. We do not sell to patients.

DMT-dC(bz) Phosphoramidite Chemical Structure

CAS No. : 102212-98-6

Size	Price	Stock	Quantity
1 g	USD 25	In-stock	Estimated Time of Arrival: December 31
5 g	USD 85	Get quote	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DMT-dC(bz) Phosphoramidite:

DMT-dC(bz) Phosphoramidite-¹³C₉,¹⁵N₃ Get quote

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Biological Activity
Purity & Documentation
References
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Description

DMT-dC(bz) Phosphoramidite is typically used in the synthesis of DNA^[1].

Molecular Weight

833.91

Formula

C₄₆H₅₂N₅O₈P

CAS No.

102212-98-6

Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@H](N5C(N=C(NC(C6=CC=CC=C6)=O)C=C5)=O)O4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (119.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1992 mL	5.9959 mL	11.9917 mL
5 mM	0.2398 mL	1.1992 mL	2.3983 mL
10 mM	0.1199 mL	0.5996 mL	1.1992 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (3.00 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.00 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (280 KB) SDS (393 KB)

COA (262 KB) HNMR (337 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. James D Thorpe, et al. Mechanochemical Synthesis of Short DNA Fragments. Chemistry. 2020 Jul 22;26(41):8857-8861. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1992 mL	5.9959 mL	11.9917 mL	29.9793 mL
	5 mM	0.2398 mL	1.1992 mL	2.3983 mL	5.9959 mL
	10 mM	0.1199 mL	0.5996 mL	1.1992 mL	2.9979 mL
	15 mM	0.0799 mL	0.3997 mL	0.7994 mL	1.9986 mL
	20 mM	0.0600 mL	0.2998 mL	0.5996 mL	1.4990 mL
	25 mM	0.0480 mL	0.2398 mL	0.4797 mL	1.1992 mL
	30 mM	0.0400 mL	0.1999 mL	0.3997 mL	0.9993 mL
	40 mM	0.0300 mL	0.1499 mL	0.2998 mL	0.7495 mL
	50 mM	0.0240 mL	0.1199 mL	0.2398 mL	0.5996 mL
	60 mM	0.0200 mL	0.0999 mL	0.1999 mL	0.4997 mL
	80 mM	0.0150 mL	0.0749 mL	0.1499 mL	0.3747 mL
	100 mM	0.0120 mL	0.0600 mL	0.1199 mL	0.2998 mL