Dofequidar sesquifumarate (Synonyms: MS-209 sesquifumarate)

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Dofequidar sesquifumarate (MS-209) is a novel quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR.

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Dofequidar sesquifumarate Chemical Structure

CAS No. : 158681-49-3

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Other In-stock Forms of Dofequidar sesquifumarate:

Dofequidar fumarate

Other Forms of Dofequidar sesquifumarate:

Dofequidar fumarate In-stock
Dofequidar Get quote

2 Publications Citing Use of MCE Dofequidar sesquifumarate

Cell Viability Assay

: Dofequidar sesquifumarate purchased from MedChemExpress. Usage Cited in: Am J Transl Res. 2020 May 15;12(5):1807-1823. [Abstract]; CCK-8 assay showing a significantly lower cisplatin IC50 for the P-gp inhibitor Dofequidar fumarate (5 μM) treatment group compared with the vehicle control group in MG-63 and MNNG/HOS cells.

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Description	Dofequidar sesquifumarate (MS-209) is a novel quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR^[1].
Molecular Weight	1311.39
Formula	C₃₀H₃₁N₃O₃.3/2C₄H₄O₄
CAS No.	158681-49-3
SMILES	OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC3.O=C(O)/C=C/C(O)=O.[1.5]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Naito M, et al. MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. Clin Cancer Res. 2002 Feb;8(2):582-8. [Content Brief] [2]. Nokihara H, et al. A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells. Jpn J Cancer Res. 2001 Jul;92(7):785-92. [Content Brief] [3]. Nakanishi O, et al. Potentiation of the antitumor activity by a novel quinoline compound, MS-209, in multidrug-resistant solid tumor cell lines. Oncol Res. 1997;9(2):61-9. [Content Brief]

Dofequidar sesquifumarate Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dofequidar sesquifumarate158681-49-3MS-209 sesquifumarateP-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243MS-209Inhibitorinhibitorinhibit

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