2. Immunology/Inflammation
  3. FAP
  4. FAPI-46

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers.

For research use only. We do not sell to patients.

FAPI-46 Chemical Structure

FAPI-46 Chemical Structure

CAS No. : 2374782-04-2

Size Price Stock Quantity
1 mg USD 360 In-stock
5 mg USD 900 In-stock
10 mg USD 1650 In-stock
25 mg USD 3300 In-stock
50 mg USD 5280 In-stock
100 mg USD 8500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

FAPI-46 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE FAPI-46

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers[1][2].

IC50 & Target

fibroblast activation protein (FAP)[1]
In Vitro

FAPI-46 (1-24 h) robustly binds to human FAP in human FAP-expressing HT-1080 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FAPI-46 Related Antibodies
In Vivo

FAPI-46 (i.v.) shows improved ratios of tumor to liver, kidney, and brain uptake, resulting in an enhanced image contrast for PET imaging[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

885.96

Formula

C41H57F2N11O9
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=NC(C=C2)=C1C=C2N(C)CCCN(CC3)CCN3C(CN(CCN(CC4)CC(O)=O)CCN(CCN4CC(O)=O)CC(O)=O)=O)NCC(N(CC5(F)F)[C@@H](C5)C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (112.87 mM; Need ultrasonic)

DMSO : 100 mg/mL (112.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1287 mL 5.6436 mL 11.2872 mL
5 mM 0.2257 mL 1.1287 mL 2.2574 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5.75 mg/mL (6.49 mM); Clear solution

    This protocol yields a clear solution of ≥ 5.75 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (57.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (5.64 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.57%

SDS (252 KB)

COA (247 KB) RP-HPLC (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.1287 mL 5.6436 mL 11.2872 mL 28.2180 mL
5 mM 0.2257 mL 1.1287 mL 2.2574 mL 5.6436 mL
10 mM 0.1129 mL 0.5644 mL 1.1287 mL 2.8218 mL
15 mM 0.0752 mL 0.3762 mL 0.7525 mL 1.8812 mL
20 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4109 mL
25 mM 0.0451 mL 0.2257 mL 0.4515 mL 1.1287 mL
30 mM 0.0376 mL 0.1881 mL 0.3762 mL 0.9406 mL
40 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7054 mL
50 mM 0.0226 mL 0.1129 mL 0.2257 mL 0.5644 mL
60 mM 0.0188 mL 0.0941 mL 0.1881 mL 0.4703 mL
80 mM 0.0141 mL 0.0705 mL 0.1411 mL 0.3527 mL
100 mM 0.0113 mL 0.0564 mL 0.1129 mL 0.2822 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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FAPI-46 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAPI-462374782-04-2FAPI46FAPI 46FAPFibroblast activation proteinquinolinefibroblastactivationproteinradiotracertumorimagingcancerInhibitorinhibitorinhibit

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