G-5758

Cat. No.: HY-161672 Purity: 98.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

G-5758 is an orally available IRE1α inhibitor with an IC₅₀ of 38 nM for XBP1s. G-5758 is well tolerated in multiple myeloma models (KMS-11) at oral doses up to 500 mg/kg in rats. G-5758 exhibits pharmacodynamics comparable to that of induced IRE1 knockdown.

For research use only. We do not sell to patients.

G-5758 Chemical Structure

CAS No. : 2413455-99-7

Size		Stock
5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability
50 mg		Check price and availability

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This product is a controlled substance and not for sale in your territory.

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Description

Molecular Weight

588.58

Formula

C₂₇H₂₄F₄N₆O₃S

CAS No.

2413455-99-7

Appearance

Solid

Color

White to off-white

SMILES

FC1=C(F)C(NS(CC2=CC=CC=C2)(=O)=O)=C(F)C=C1OC3=C(C=CC=N3)C4=CC=NC(N[C@H]5C[C@H](F)CNC5)=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (169.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6990 mL	8.4950 mL	16.9900 mL
5 mM	0.3398 mL	1.6990 mL	3.3980 mL
10 mM	0.1699 mL	0.8495 mL	1.6990 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.91%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB) HNMR (141 KB) RP-HPLC (138 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Braun MG, et al. Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model. J Med Chem. 2024 Jun 13;67(11):8708-8729. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6990 mL	8.4950 mL	16.9900 mL	42.4751 mL
	5 mM	0.3398 mL	1.6990 mL	3.3980 mL	8.4950 mL
	10 mM	0.1699 mL	0.8495 mL	1.6990 mL	4.2475 mL
	15 mM	0.1133 mL	0.5663 mL	1.1327 mL	2.8317 mL
	20 mM	0.0850 mL	0.4248 mL	0.8495 mL	2.1238 mL
	25 mM	0.0680 mL	0.3398 mL	0.6796 mL	1.6990 mL
	30 mM	0.0566 mL	0.2832 mL	0.5663 mL	1.4158 mL
	40 mM	0.0425 mL	0.2124 mL	0.4248 mL	1.0619 mL
	50 mM	0.0340 mL	0.1699 mL	0.3398 mL	0.8495 mL
	60 mM	0.0283 mL	0.1416 mL	0.2832 mL	0.7079 mL
	80 mM	0.0212 mL	0.1062 mL	0.2124 mL	0.5309 mL
	100 mM	0.0170 mL	0.0850 mL	0.1699 mL	0.4248 mL

G-5758 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G-57582413455-99-7G5758G 5758LiposomeIRE1Inositol requiring enzyme 1Inhibitorinhibitorinhibit

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