Gavestinel sodium salt (Synonyms: GV 150526A)

Name: Gavestinel sodium salt
Brand: MedChemExpress
SKU: HY-107700
Rating: 4.5 (1 reviews)

Cat. No.: HY-107700 Purity: 99.38%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gavestinel (GV 150526A) is a potent, selective, orally active and non-competitive antagonist of NMDA receptor. Gavestinel binds to the glycine site of the NMDA receptor, with a pK_i of 8.5. Gavestinel can be used for the research of acute ischemic stroke.

For research use only. We do not sell to patients.

Gavestinel sodium salt Chemical Structure

CAS No. : 153436-38-5

Size	Price	Stock	Quantity
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Gavestinel sodium salt:

Gavestinel Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

NMDA Receptor

Molecular Weight

397.19

Formula

C₁₈H₁₁Cl₂N₂NaO₃

CAS No.

153436-38-5

Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC1=CC=CC=C1)/C=C/C2=C(C(O[Na])=O)NC3=CC(Cl)=CC(Cl)=C23

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (251.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5177 mL	12.5884 mL	25.1769 mL
5 mM	0.5035 mL	2.5177 mL	5.0354 mL
10 mM	0.2518 mL	1.2588 mL	2.5177 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.38%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (258 KB) HNMR (264 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Fabio RD, et, al. Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site. J Med Chem. 1997 Mar 14;40(6):841-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5177 mL	12.5884 mL	25.1769 mL	62.9422 mL
	5 mM	0.5035 mL	2.5177 mL	5.0354 mL	12.5884 mL
	10 mM	0.2518 mL	1.2588 mL	2.5177 mL	6.2942 mL
	15 mM	0.1678 mL	0.8392 mL	1.6785 mL	4.1961 mL
	20 mM	0.1259 mL	0.6294 mL	1.2588 mL	3.1471 mL
	25 mM	0.1007 mL	0.5035 mL	1.0071 mL	2.5177 mL
	30 mM	0.0839 mL	0.4196 mL	0.8392 mL	2.0981 mL
	40 mM	0.0629 mL	0.3147 mL	0.6294 mL	1.5736 mL
	50 mM	0.0504 mL	0.2518 mL	0.5035 mL	1.2588 mL
	60 mM	0.0420 mL	0.2098 mL	0.4196 mL	1.0490 mL
	80 mM	0.0315 mL	0.1574 mL	0.3147 mL	0.7868 mL
	100 mM	0.0252 mL	0.1259 mL	0.2518 mL	0.6294 mL

Gavestinel sodium salt Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gavestinel153436-38-5GV 150526AiGluRIonotropic glutamate receptorsNMDA receptoracute ischemic strokeInhibitorinhibitorinhibit

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Gavestinel sodium salt (Synonyms: GV 150526A)

Customer Review

Other Forms of Gavestinel sodium salt:

Gavestinel sodium salt Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All iGluR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Gavestinel sodium salt Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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