JMJD7 - jumonji domain containing 7 Gene

Homo sapiens

Gene ID: 100137047 | Gene type: protein coding

About JMJD7

This gene has 6 transcripts (splice variants), 171 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 20.1), esophagus (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream Phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the Phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]

JMJD7 Products(1)

mRNA	Protein	Name
NM_001114632.2	NP_001108104.1	bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminopeptidase activity	IDA IDA: Inferred from direct assay	28847961	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	28847961	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	28847961	GOA
enables monooxygenase activity	IDA IDA: Inferred from direct assay	29915238	GOA
enables peptidyl-lysine 3-dioxygenase activity	EXP EXP: Inferred from Experiment	29915238	GOA
enables peptidyl-lysine 3-dioxygenase activity	IDA IDA: Inferred from direct assay	29915238	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein hydroxylation	IDA IDA: Inferred from direct assay	29915238	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	29915238	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29915238	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JMJD7 Protein Structure

Cupin_8

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7

L-lysine (3S)-hydroxylase JMJD7

JMJD7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	JMJD7	P0C870	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	JMJD7	P0C870	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	JMJD7	P0C870	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	JMJD7	P0C870	POM121	Homo sapiens	Q96HA1-2	Validated Y2H	32296183
Intra	JMJD7	P0C870	FOXI1	Homo sapiens	Q12951-2	Validated Y2H	32296183
Intra	JMJD7	P0C870	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	JMJD7	P0C870	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	JMJD7	P0C870	OXER1	Homo sapiens	Q8TDS5	Validated Y2H	32296183
Intra	JMJD7	P0C870	SAMD11	Homo sapiens	Q96NU1	Validated Y2H	32296183
Intra	JMJD7	P0C870	VAC14	Homo sapiens	Q08AM6	Y2H Array	25416956
Intra	JMJD7	P0C870	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	25416956
Intra	JMJD7	P0C870	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	JMJD7	P0C870	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	JMJD7	P0C870	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	JMJD7	P0C870	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	JMJD7	P0C870	UBAP2	Homo sapiens	Q5T6F2	Y2H Prey Pooling	32296183
Intra	JMJD7	P0C870	UBAP2	Homo sapiens	Q5T6F2	Validated Y2H	32296183
Intra	JMJD7	P0C870	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	JMJD7	P0C870	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	JMJD7	P0C870	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	JMJD7	P0C870	RAN	Homo sapiens	P62826	Y2H Array	32814053
Intra	JMJD7	P0C870	RAN	Homo sapiens	P62826	Y2H Pooling	32814053
Intra	JMJD7	P0C870	RAN	Homo sapiens	P62826	Validated Y2H	32814053
Intra	JMJD7	P0C870	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	JMJD7	P0C870	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	JMJD7	P0C870	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	JMJD7	P0C870	PRPF40A	Homo sapiens	O75400-2	Validated Y2H	32814053
Intra	JMJD7	P0C870	PRPF40A	Homo sapiens	O75400-2	Y2H Array	32814053
Intra	JMJD7	P0C870	PRPF40A	Homo sapiens	O75400-2	Y2H Pooling	32814053
Intra	JMJD7	P0C870	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	JMJD7	P0C870	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	JMJD7	P0C870	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	JMJD7	P0C870	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	JMJD7	P0C870	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	JMJD7	P0C870	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	JMJD7	P0C870	DRG2	Homo sapiens	P55039	Validated Y2H	32296183
Intra	JMJD7	P0C870	DRG2	Homo sapiens	P55039	Y2H Prey Pooling	32296183
Intra	JMJD7	P0C870	DRG2	Homo sapiens	P55039	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132198	JMJD7-IN-1	Inhibitor	98.57%	Unkown
HY-RS07040	JMJD7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	JMJD7	VGNC	VGNC:55118
Rattus norvegicus	JMJD7	RGD	RGD:2290039
Mus musculus	JMJD7	MGD	MGI:3845785
Canis familiaris	JMJD7	VGNC	VGNC:59115

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