2. Gene
  3. JMJD7 - jumonji domain containing 7 Gene

JMJD7 - jumonji domain containing 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 100137047 | Gene type: protein coding

About JMJD7

This gene has 6 transcripts (splice variants), 171 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 20.1), esophagus (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream Phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the Phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]

JMJD7 Products(1)

mRNA Protein Name
NM_001114632.2 NP_001108104.1 bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
28847961 GOA
enables endopeptidase activity IDA
IDA: Inferred from direct assay
28847961 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
28847961 GOA
enables monooxygenase activity IDA
IDA: Inferred from direct assay
29915238 GOA
enables peptidyl-lysine 3-dioxygenase activity EXP
EXP: Inferred from Experiment
29915238 GOA
enables peptidyl-lysine 3-dioxygenase activity IDA
IDA: Inferred from direct assay
29915238 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein hydroxylation IDA
IDA: Inferred from direct assay
29915238 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
29915238 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29915238 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JMJD7 Protein Structure

Cupin_8

Cupin_8: Cupin-like domain (40 - 297)

  • 0
  • 100
  • 200
  • 316 a.a.
Protein Preferred Names Protein Names

bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7

L-lysine (3S)-hydroxylase JMJD7

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132198 JMJD7-IN-1 Inhibitor 98.57% Unkown
HY-RS07040 JMJD7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus JMJD7 VGNC VGNC:55118
Rattus norvegicus JMJD7 RGD RGD:2290039
Mus musculus JMJD7 MGD MGI:3845785
Canis familiaris JMJD7 VGNC VGNC:59115