2. Gene
  3. SAMD11 - sterile alpha motif domain containing 11 Gene

SAMD11 - sterile alpha motif domain containing 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MRS

Gene ID: 148398 | Gene type: protein coding

About SAMD11

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:923,923-944,574 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 7.4), endometrium (RPKM 5.9) and 25 other tissues.

Summary

Predicted to enable several functions, including histone binding activity; protein domain specific binding activity; and protein self-association. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SAMD11 Products(3)

mRNA Protein Name
NM_001385640.1 NP_001372569.1 sterile alpha motif domain-containing protein 11 isoform 2
NM_001385641.1 NP_001372570.1 sterile alpha motif domain-containing protein 11 isoform 1
NM_152486.4 NP_689699.3 sterile alpha motif domain-containing protein 11 isoform 3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAMD11 Protein Structure

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (543 - 597)

  • 0
  • 200
  • 400
  • 600
  • 681 a.a.
Protein Preferred Names Protein Names

sterile alpha motif domain-containing protein 11

SAM domain-containing protein 11

SAMD11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SAMD11 Q96NU1 RTL8C Homo sapiens A6ZKI3
Y2H Array
32296183
Intra SAMD11 Q96NU1 RTL8C Homo sapiens A6ZKI3
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra SAMD11 Q96NU1 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
Intra SAMD11 Q96NU1 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra SAMD11 Q96NU1 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra SAMD11 Q96NU1 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra SAMD11 Q96NU1 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra SAMD11 Q96NU1 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra SAMD11 Q96NU1 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 PRR20D Homo sapiens P86480
Y2H Array
32296183
Intra SAMD11 Q96NU1 PRR20D Homo sapiens P86480
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra SAMD11 Q96NU1 PLAGL2 Homo sapiens Q9UPG8
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 PLAGL2 Homo sapiens Q9UPG8
Validated Y2H
32296183
Intra SAMD11 Q96NU1 PLAGL2 Homo sapiens Q9UPG8
Y2H Array
32296183
Intra SAMD11 Q96NU1 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra SAMD11 Q96NU1 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra SAMD11 Q96NU1 TRIB3 Homo sapiens Q96RU7
Validated Y2H
32296183
Intra SAMD11 Q96NU1 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra SAMD11 Q96NU1 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 CT55 Homo sapiens Q8WUE5
Y2H Array
32296183
Intra SAMD11 Q96NU1 CT55 Homo sapiens Q8WUE5
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra SAMD11 Q96NU1 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra SAMD11 Q96NU1 JMJD7 Homo sapiens P0C870
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 JMJD7 Homo sapiens P0C870
Y2H Array
32296183
Intra SAMD11 Q96NU1 ECM1 Homo sapiens Q16610
Y2H Array
32296183
Intra SAMD11 Q96NU1 ECM1 Homo sapiens Q16610
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra SAMD11 Q96NU1 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra SAMD11 Q96NU1 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Intra SAMD11 Q96NU1 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chronic Intestinal Vascular Insufficiency

Chronic Mesenteric Ischemia

Cmi - Chronic Mesenteric Ischaemia
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12423 SAMD11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SAMD11 VGNC VGNC:45849
Bos taurus SAMD11 VGNC VGNC:59361
Felis catus SAMD11 VGNC VGNC:64861
Rattus norvegicus SAMD11 RGD RGD:1310271
Mus musculus SAMD11 MGD MGI:2446220