OXER1 - oxoeicosanoid receptor 1 Gene

Homo sapiens

Also known as GPCR; GPR170; TG1019

Gene ID: 165140 | Gene type: protein coding

About OXER1

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,762,499-42,764,135 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues and 15 paralogues.

Summary

Enables G protein-coupled receptor activity and icosanoid binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

OXER1 Products(1)

mRNA	Protein	Name
NM_148962.5	NP_683765.2	oxoeicosanoid receptor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding	IDA IDA: Inferred from direct assay	12065583	GOA
enables 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding	IDA IDA: Inferred from direct assay	12065583	GOA
enables 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding	IDA IDA: Inferred from direct assay	12065583	GOA
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	12065583	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12065583	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OXER1 Protein Structure

7tm_1

0
100
200
300
400
423 a.a.

Protein Preferred Names

Protein Names

oxoeicosanoid receptor 1

5-oxo-ETE G-protein coupled receptor

OXER1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OXER1	Q8TDS5	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	ASB13	Homo sapiens	Q8WXK3-2	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	ANAPC11	Homo sapiens	Q9NYG5-2	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	RNF38	Homo sapiens	Q9H0F5	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	NOC4L	Homo sapiens	Q9BVI4	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	RAMAC	Homo sapiens	Q9BTL3	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	RNF208	Homo sapiens	Q9H0X6	Validated Y2H	32296183
Intra	OXER1	Q8TDS5	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09887	OXER1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-141434	5-OxoETE methyl ester	Agonist	/	Unkown

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