MED23 - mediator complex subunit 23 Gene

Homo sapiens

Also known as SUR2; CRSP3; MRT18; SUR-2; ARC130; CRSP130; CRSP133; DRIP130

Gene ID: 9439 | Gene type: protein coding

About MED23

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,573,966-131,628,313 (from NCBI)

This gene has 9 transcripts (splice variants), 201 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 9.5), lymph node (RPKM 8.5) and 25 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

MED23 Products(12)

mRNA	Protein	Name
NM_001270521.2	NP_001257450.1	mediator of RNA polymerase II transcription subunit 23 isoform c
NM_001270522.2	NP_001257451.1	mediator of RNA polymerase II transcription subunit 23 isoform d
NM_001376517.1	NP_001363446.1	mediator of RNA polymerase II transcription subunit 23 isoform e
NM_001376518.1	NP_001363447.1	mediator of RNA polymerase II transcription subunit 23 isoform f
NM_001376519.1	NP_001363448.1	mediator of RNA polymerase II transcription subunit 23 isoform g
NM_001376520.1	NP_001363449.1	mediator of RNA polymerase II transcription subunit 23 isoform h
NM_001376521.1	NP_001363450.1	mediator of RNA polymerase II transcription subunit 23 isoform i
NM_001376522.1	NP_001363451.1	mediator of RNA polymerase II transcription subunit 23 isoform j
NM_001376523.1	NP_001363452.1	mediator of RNA polymerase II transcription subunit 23 isoform k
NM_001376524.1	NP_001363453.1	mediator of RNA polymerase II transcription subunit 23 isoform l
NM_004830.4	NP_004821.2	mediator of RNA polymerase II transcription subunit 23 isoform a
NM_015979.4	NP_057063.2	mediator of RNA polymerase II transcription subunit 23 isoform b

MED23 Protein Structure

Med23

0
300
600
900
1200
1368 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 23

130 kDa transcriptional co-activator

MED23 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	Y2H	12421765
Intra	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	Anti Tag CoIP	33961781
Intra	MED23	Q9ULK4	MED13	Homo sapiens	Q9UHV7	BioID	25281560
Intra	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Anti Tag CoIP	24882805
Intra	MED23	Q9ULK4	MED14	Homo sapiens	O60244	BioID	25281560
Intra	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Pull Down	25281560
Intra	MED23	Q9ULK4	MED14	Homo sapiens	O60244	Anti Tag CoIP	33961781
Intra	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	BioID	25281560
Intra	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	Pull Down	25281560
Intra	MED23	Q9ULK4	MED16	Homo sapiens	Q9Y2X0	Anti Tag CoIP	33961781
Intra	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	Anti Tag CoIP	33961781
Intra	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	BioID	25281560
Intra	MED23	Q9ULK4	MED25	Homo sapiens	Q71SY5	Pull Down	25281560

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 18, With Or Without Epilepsy

Intellectual Developmental Disorder, Autosomal Recessive 18	MRT18
Mental Retardation, Autosomal Recessive 18	Autosomal Recessive Intellectual Developmental Disorder 18
Mental Retardation, Autosomal Recessive, Type 18

Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Intellectual Disability-18

Argininemia

Hyperargininemia	Arginase Deficiency
Arg1 Deficiency	Arginase-1 Deficiency
Deficiency Of Canavanase	Arginase Deficiency Disease
ARGIN

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type

Methylcobalamin Deficiency, Cblg Type	HMAG
Methionine Synthase Deficiency	Methylcobalamin Deficiency Type Cblg
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism, Cblg Complementation Type	Homocystinuria-Megaloblastic Anemia Cblg Type
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cblg Complementation Type	Methylcobalamin Deficiency Cbl G Type
Homocystinuria Due To Defect In Methylation Cbl G	Cblg
Functional Methionine Synthase Deficiency Type Cblg	Methylcobalamin Deficiency Cblg Type
Arakawa Syndrome 2

Opitz-Kaveggia Syndrome

Fg Syndrome	Fgs1
Fgs	Keller Syndrome
OKS	Fg Syndrome 1
Fg Syndrome Type 1	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum
Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158005	Anticancer agent 195	Inducer	/	Unkown
HY-RS08294	MED23 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MED23	VGNC	VGNC:43131
Bos taurus	MED23	VGNC	VGNC:31360
Mus musculus	MED23	MGD	MGI:1917458
Rattus norvegicus	MED23	RGD	RGD:1307671
Macaca mulatta	MED23	VGNC	VGNC:74562
Felis catus	MED23	VGNC	VGNC:102459

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