NUBP2 - NUBP iron-sulfur cluster assembly factor 2, cytosolic Gene

Homo sapiens

Also known as CFD1; CIAO6; NBP 2; NUBP1

Gene ID: 10101 | Gene type: protein coding

About NUBP2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,782,960-1,789,186 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 8.3), prostate (RPKM 7.4) and 25 other tissues.

Summary

This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

NUBP2 Products(3)

mRNA	Protein	Name
NM_001284501.2	NP_001271430.1	cytosolic Fe-S cluster assembly factor NUBP2 isoform 2
NM_001284502.2	NP_001271431.1	cytosolic Fe-S cluster assembly factor NUBP2 isoform 3
NM_012225.4	NP_036357.1	cytosolic Fe-S cluster assembly factor NUBP2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18573874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUBP2 Protein Structure

AAA_31

ParA

0
100
200
271 a.a.

Protein Preferred Names

Protein Names

cytosolic Fe-S cluster assembly factor NUBP2

homolog of yeast cytosolic Fe-S cluster deficient 1

NUBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUBP2	Q9Y5Y2	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	NUBP2	Q9Y5Y2	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	NUBP2	Q9Y5Y2	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	NUBP2	Q9Y5Y2	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	NUBP2	Q9Y5Y2	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	NUBP2	Q9Y5Y2	TGM1	Homo sapiens	P22735	Y2H Array	32296183
Intra	NUBP2	Q9Y5Y2	TGM1	Homo sapiens	P22735	Y2H Prey Pooling	32296183
Intra	NUBP2	Q9Y5Y2	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	NUBP2	Q9Y5Y2	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	NUBP2	Q9Y5Y2	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	NUBP2	Q9Y5Y2	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	NUBP2	Q9Y5Y2	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	NUBP2	Q9Y5Y2	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	NUBP2	Q9Y5Y2	NUBP1	Homo sapiens	P53384	Anti Tag CoIP	33961781
Intra	NUBP2	Q9Y5Y2	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	NUBP2	Q9Y5Y2	TNS2	Homo sapiens	Q63HR2	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 38

Spinocerebellar Ataxia Type 38	SCA38
Ataxia, Spinocerebellar, Type 38

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09652	NUBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NUBP2	VGNC	VGNC:68585
Bos taurus	NUBP2	VGNC	VGNC:32316
Macaca mulatta	NUBP2	VGNC	VGNC:75547
Mus musculus	NUBP2	MGD	MGI:1347072
Canis familiaris	NUBP2	VGNC	VGNC:44018
Rattus norvegicus	NUBP2	RGD	RGD:1305113

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