SGK2 - serum/glucocorticoid regulated kinase 2 Gene

Homo sapiens

Also known as H-SGK2; dJ138B7.2

Gene ID: 10110 | Gene type: protein coding

About SGK2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,559,027-43,585,627 (from NCBI)

This gene has 14 transcripts (splice variants), 199 orthologues and 13 paralogues. Biased expression in kidney (RPKM 17.8), colon (RPKM 13.6) and 8 other tissues.

Summary

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

SGK2 Products(3)

mRNA	Protein	Name
NM_001199264.2	NP_001186193.1	serine/threonine-protein kinase Sgk2
NM_016276.5	NP_057360.3	serine/threonine-protein kinase Sgk2
NM_170693.3	NP_733794.1	serine/threonine-protein kinase Sgk2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	12397388	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGK2 Protein Structure

Pkinase

Pkinase_C

0
100
200
300
400
427 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Sgk2

SGK2, serine/threonine kinase 2

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15192	GSK 650394	Inhibitor	99.76%	Unkown
HY-167832	PT109	Inhibitor	/	Unkown
HY-RS12801	SGK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SGK2	VGNC	VGNC:65079
Rattus norvegicus	SGK2	RGD	RGD:620232
Macaca mulatta	SGK2	VGNC	VGNC:77228
Mus musculus	SGK2	MGD	MGI:1351318
Bos taurus	SGK2	VGNC	VGNC:34542
Others	SGK2	NCBI

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