SSX3 - SSX family member 3 Gene

Homo sapiens

Also known as CT5.3

Gene ID: 10214 | Gene type: protein coding

About SSX3

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,346,427-48,356,703 (from NCBI)

This gene has 4 transcripts (splice variants), 107 orthologues and 7 paralogues. Restricted expression toward testis (RPKM 5.8).

Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]

SSX3 Products(1)

mRNA	Protein	Name
NM_021014.4	NP_066294.1	protein SSX3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSX3 Protein Structure

SSXRD

0
100
188 a.a.

Protein Preferred Names

Protein Names

protein SSX3

Kruppel-associated box containing gene product SSX3

SSX3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SSX3	Q99909	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	SSX3	Q99909	ZNG1A	Homo sapiens	Q9BRT8	Validated Y2H	32296183
Intra	SSX3	Q99909	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	SSX3	Q99909	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	SSX3	Q99909	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	AKAP9	Homo sapiens	Q6PJH3	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	AKAP9	Homo sapiens	Q6PJH3	Y2H Array	32296183
Intra	SSX3	Q99909	RABGEF1	Homo sapiens	Q9UJ41-4	Y2H Array	32296183
Intra	SSX3	Q99909	RABGEF1	Homo sapiens	Q9UJ41-4	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	RABGEF1	Homo sapiens	Q9UJ41-4	Validated Y2H	32296183
Intra	SSX3	Q99909	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	CMTM4	Homo sapiens	Q8IZR5-2	Y2H Array	32296183
Intra	SSX3	Q99909	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	SSX3	Q99909	CMTM5	Homo sapiens	Q96DZ9	Y2H Prey Pooling	25416956
Intra	SSX3	Q99909	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	SSX3	Q99909	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
Intra	SSX3	Q99909	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	SSX3	Q99909	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	25416956
Intra	SSX3	Q99909	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	SSX3	Q99909	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	25416956
Intra	SSX3	Q99909	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	32296183
Intra	SSX3	Q99909	MED4	Homo sapiens	Q9NPJ6	Y2H Array	25416956
Intra	SSX3	Q99909	MED4	Homo sapiens	Q9NPJ6	Y2H Array	32296183
Intra	SSX3	Q99909	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	32296183
Intra	SSX3	Q99909	RHOJ	Homo sapiens	Q9H4E5	Y2H Prey Pooling	25416956
Intra	SSX3	Q99909	RHOJ	Homo sapiens	Q9H4E5	Validated Y2H	25416956
Intra	SSX3	Q99909	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	SSX3	Q99909	AGTRAP	Homo sapiens	Q6RW13	Y2H Prey Pooling	25416956
Intra	SSX3	Q99909	CEP63	Homo sapiens	Q96MT8	Validated Y2H	25416956
Intra	SSX3	Q99909	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	SSX3	Q99909	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	SSX3	Q99909	MEOX2	Homo sapiens	P50222	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Malignant Mesenchymoma

Malignant Mesenchymal Tumor	Mesenchymoma, Malignant
Sarcoma	Rat Malignant Renal Mesenchymal Tumor

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13839	SSX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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