SSX3 - SSX family member 3 Gene

Homo sapiens

Also known as CT5.3

Gene ID: 10214 | Gene type: protein coding

About SSX3

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,346,427-48,356,703 (from NCBI)

This gene has 4 transcripts (splice variants), 107 orthologues and 7 paralogues. Restricted expression toward testis (RPKM 5.8).

Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. [provided by RefSeq, Jul 2013]

SSX3 Products(1)

mRNA	Protein	Name
NM_021014.4	NP_066294.1	protein SSX3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSX3 Protein Structure

SSXRD

0
100
188 a.a.

Protein Preferred Names

Protein Names

protein SSX3

Kruppel-associated box containing gene product SSX3

Related Diseases

Diseases

Alias

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Malignant Mesenchymoma

Malignant Mesenchymal Tumor	Mesenchymoma, Malignant
Sarcoma	Rat Malignant Renal Mesenchymal Tumor

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13839	SSX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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