2. Gene
  3. KLRG1 - killer cell lectin like receptor G1 Gene

KLRG1 - killer cell lectin like receptor G1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE

Gene ID: 10219 | Gene type: protein coding

About KLRG1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,950,044-9,215,570 (from NCBI)

This gene has 7 transcripts (splice variants), 107 orthologues and 23 paralogues. Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.1) and 23 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]

KLRG1 Products(5)

mRNA Protein Name
NM_001329099.2 NP_001316028.1 killer cell lectin-like receptor subfamily G member 1 isoform a
NM_001329101.2 NP_001316030.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_001329102.2 NP_001316031.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_001329103.2 NP_001316032.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_005810.4 NP_005801.3 killer cell lectin-like receptor subfamily G member 1 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLRG1 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (93 - 186)

  • 0
  • 100
  • 195 a.a.
Protein Preferred Names Protein Names

killer cell lectin-like receptor subfamily G member 1

C-type lectin domain family 15 member A

KLRG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KLRG1 Q96E93 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
KLRG1 Q96E93 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
KLRG1 Q96E93 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
KLRG1 Q96E93 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
KLRG1 Q96E93 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
KLRG1 Q96E93 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
KLRG1 Q96E93 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra
KLRG1 Q96E93 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra
KLRG1 Q96E93 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
KLRG1 Q96E93 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
KLRG1 Q96E93 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
KLRG1 Q96E93 LEPROTL1 Homo sapiens O95214
Y2H Pooling
16189514
Intra
KLRG1 Q96E93 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra
KLRG1 Q96E93 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KLRG1 Proteins

Cat. No. Product Name Accession Purity
HY-P71607 KLRG1 Protein, Human (His-SUMO) Q96E93 (L60-F195) ≥95%

Related Diseases

Diseases Alias
Mastocytosis

Mast Cell Disease

Mast Cell Hyperplasia

Urticaria Pigmentosa

Malignant Mastocytoma

Malignant Mast Cell Tumours

Malignant Mastocytosis
Thyroid Dyshormonogenesis 3

TDH3

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 3

Thyroid Hormonogenesis, Genetic Defect In, 3

Genetic Defect In Thyroid Hormonogenesis 3

Chdh3

Congenital Hypothyroidism Due To Dyshormonogenesis Type 3

Genetic Defect In Thyroid Hormonogenesis Type 3
Mast-Cell Leukemia

Mast Cell Leukemia

Leukemia, Mast-Cell

Leukemia Mast Cell

Mast Cell Leukaemia Nos

Mast Cell Leukaemia Without Mention Of Remission
Macular Degeneration, Age-Related, 8

Age Related Macular Degeneration 8

ARMD8

Macular Degeneration, Age-Related, Type 8
Systemic Mastocytosis

Systemic Mast Cell Disease

Systemic Tissue Mast Cell Disease

Mastocytosis, Systemic

Smcd - Systemic Mast Cell Disease

Smcd

Mast Cell Disease, Systemic

Systemic Mast-Cell Disease

Systemic Mastocytoses

Mastocytosis Systemic

Corneal Dystrophy, Subepithelial Mucinous

Smcd - [Systemic Mast Cell Disease]
Listeriosis

Listeria Infection

Infection By Listeria Monocytogenes

Listeria Monocytogenes Infection

Listeria Infections

Listerial Foodborne Infection

Circling Disease

Infection Due To Listeria Monocytogenes

Listerellosis
Dermatitis, Atopic, 5

ATOD5

Atopic Dermatitis 5

Dermatitis, Atopic, Susceptibility To, 5

Dermatitis, Atopic 5
Bronchiectasis 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07397 KLRG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KLRG1 VGNC VGNC:74196
Rattus norvegicus KLRG1 RGD RGD:61978
Bos taurus KLRG1 VGNC VGNC:30687
Canis familiaris KLRG1 VGNC VGNC:42487
Mus musculus KLRG1 MGD MGI:1355294
Others KLRG1 NCBI