2. Gene
  3. PAK4 - p21 (RAC1) activated kinase 4 Gene

PAK4 - p21 (RAC1) activated kinase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 10298 | Gene type: protein coding

About PAK4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,125,786-39,182,816 (from NCBI)

This gene has 12 transcripts (splice variants), 162 orthologues and 35 paralogues. Ubiquitous expression in prostate (RPKM 14.9), kidney (RPKM 12.6) and 25 other tissues.

Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to Cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin Cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PAK4 Products(18)

mRNA Protein Name
XM_011526320.2 XP_011524622.1 serine/threonine-protein kinase PAK 4 isoform X2
XM_047438036.1 XP_047293992.1 serine/threonine-protein kinase PAK 4 isoform X1
XM_011526317.3 XP_011524619.1 serine/threonine-protein kinase PAK 4 isoform X1
XM_011526316.2 XP_011524618.1 serine/threonine-protein kinase PAK 4 isoform X1
NM_001394501.1 NP_001381430.1 serine/threonine-protein kinase PAK 4 isoform 1
XM_047438041.1 XP_047293997.1 serine/threonine-protein kinase PAK 4 isoform X2
XM_047438035.1 XP_047293991.1 serine/threonine-protein kinase PAK 4 isoform X1
XM_047438034.1 XP_047293990.1 serine/threonine-protein kinase PAK 4 isoform X1
XM_024451314.2 XP_024307082.1 serine/threonine-protein kinase PAK 4 isoform X2
NM_001014833.1
XM_047438040.1 XP_047293996.1 serine/threonine-protein kinase PAK 4 isoform X2
XM_047438038.1 XP_047293994.1 serine/threonine-protein kinase PAK 4 isoform X1
NM_001014835.2 NP_001014835.1 serine/threonine-protein kinase PAK 4 isoform 2
NM_001014832.2 NP_001014832.1 serine/threonine-protein kinase PAK 4 isoform 1
NM_001014834.3 NP_001014834.1 serine/threonine-protein kinase PAK 4 isoform 2
NM_001014831.3 NP_001014831.1 serine/threonine-protein kinase PAK 4 isoform 1
XM_047438037.1 XP_047293993.1 serine/threonine-protein kinase PAK 4 isoform X1
NM_005884.5 NP_005875.1 serine/threonine-protein kinase PAK 4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
26607847 GOA
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
21788589 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21788589 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
21788589 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK4 Protein Structure

PBD

PBD: P21-Rho-binding domain (10 - 63)

Pkinase

Pkinase: Protein kinase domain (326 - 572)

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  • 591 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 4

p21 protein (Cdc42/Rac)-activated kinase 4

p21(CDKN1A)-activated kinase 4

protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs

Recombinant PAK4 Proteins

Cat. No. Product Name Accession Purity
HY-P700575 PAK4 Protein, Human (His-SUMO) O96013 (M1-R426) ≥95%

Related Diseases

Diseases Alias
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-12793 Padnarsertib Inhibitor 99.86% Phase 2
HY-13007 PF-3758309 Inhibitor 99.84% Phase 1
HY-13007A PF-3758309 hydrochloride Inhibitor / Phase 1
HY-13007B PF-3758309 dihydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19538 FRAX1036 Inhibitor 99.49% Unkown
HY-125035 LCH-7749944 Inhibitor 99.36% Unkown
HY-146681 PAK1-IN-1 Inhibitor / Unkown
HY-130628 PAK4-IN-1 Inhibitor / Unkown
HY-159897 PAK4-IN-5 Inhibitor / Unkown
HY-117218 KY-04045 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PAK4 VGNC VGNC:53528
Mus musculus PAK4 MGD MGI:1917834
Rattus norvegicus PAK4 RGD RGD:1307705
Others PAK4 NCBI