INKA1 - inka box actin regulator 1 Gene

Homo sapiens

Also known as C3orf54; FAM212A

Gene ID: 389119 | Gene type: protein coding

About INKA1

This gene has 1 transcript (splice variant), 263 orthologues and 1 paralogue. Broad expression in skin (RPKM 6.6), lung (RPKM 3.2) and 23 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be involved in negative regulation of catalytic activity. Predicted to act upstream of or within neural tube development. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

INKA1 Products(2)

mRNA	Protein	Name
NM_001366281.1	NP_001353210.1	PAK4-inhibitor INKA1 isoform 2
NM_203370.2	NP_976248.2	PAK4-inhibitor INKA1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	26607847	GOA
enables protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	26607847	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26607847	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26607847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INKA1 Protein Structure

FAM212

0
100
200
287 a.a.

Protein Preferred Names

Protein Names

PAK4-inhibitor INKA1

HInca

INKA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	INKA1	Q96EL1	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32814053
Intra	INKA1	Q96EL1	BSCL2	Homo sapiens	J3KQ12	Validated Y2H	32814053
Intra	INKA1	Q96EL1	BSCL2	Homo sapiens	J3KQ12	Y2H Pooling	32814053
Intra	INKA1	Q96EL1	PEX7	Homo sapiens	O00628-2	Y2H Array	32814053
Intra	INKA1	Q96EL1	PEX7	Homo sapiens	O00628-2	Validated Y2H	32814053
Intra	INKA1	Q96EL1	PEX7	Homo sapiens	O00628-2	Y2H Pooling	32814053
Intra	INKA1	Q96EL1	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	INKA1	Q96EL1	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	INKA1	Q96EL1	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	INKA1	Q96EL1	PAK4	Homo sapiens	O96013	Anti Tag CoIP	33961781
Intra	INKA1	Q96EL1	PAK5	Homo sapiens	Q9P286	MAPPIT	25416956
Intra	INKA1	Q96EL1	PAK5	Homo sapiens	Q9P286	Y2H Array	31515488
Intra	INKA1	Q96EL1	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
Intra	INKA1	Q96EL1	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Visual Cortex Disease

Visual Cortex Dysfunction	Visual Cortex Disorder
Visual Cortical Disorder	Disease Of Visual Cortex

Visual Pathway Disease

Disorder Of Visual Pathways

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06818	INKA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INKA1	VGNC	VGNC:28790
Felis catus	INKA1	VGNC	VGNC:62925
Canis familiaris	INKA1	VGNC	VGNC:40659
Mus musculus	INKA1	MGD	MGI:1915426
Macaca mulatta	INKA1	VGNC	VGNC:73692
Rattus norvegicus	INKA1	RGD	RGD:1560778

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