RRAGB - Ras related GTP binding B Gene

Homo sapiens

Also known as RAGB; bA465E19.1

Gene ID: 10325 | Gene type: protein coding

About RRAGB

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:55,717,749-55,758,774 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 5.3), thyroid (RPKM 4.8) and 25 other tissues.

Summary

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

RRAGB Products(4)

mRNA	Protein	Name
NM_001354011.2	NP_001340940.1	ras-related GTP-binding protein B isoform 3
NM_001354013.2	NP_001340942.1	ras-related GTP-binding protein B isoform 4
NM_006064.5	NP_006055.3	ras-related GTP-binding protein B short isoform
NM_016656.4	NP_057740.2	ras-related GTP-binding protein B long isoform

RRAGB Protein Structure

Gtr1_RagA

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

ras-related GTP-binding protein B

GTP-binding protein ragB

RRAGB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RRAGB	Q5VZM2	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	25567906
Intra	RRAGB	Q5VZM2	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	11073942
Intra	RRAGB	Q5VZM2	RRAGC	Homo sapiens	Q9HB90	Anti Tag CoIP	33961781
Intra	RRAGB	Q5VZM2	RRAGD	Homo sapiens	Q9NQL2	Anti Tag CoIP	33961781
Intra	RRAGB	Q5VZM2	RRAGD	Homo sapiens	Q9NQL2	Anti Tag CoIP	20381137
Intra	RRAGB	Q5VZM2	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25567906

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

Alveolar Echinococcosis

Echinococcus Multilocularis Infection	Echinococcosis
Alveolococcosis	Multilocular Hydatid
Small Fox Tapeworm

Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome	Fibrofolliculomas With Trichodiscomas And Acrochordons
BHD	Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculoma Familial	Bhd Syndrome
Birt Hogg Dube Syndrome	Hornstein-Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12277	RRAGB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RRAGB	MGD	MGI:3038613
Bos taurus	RRAGB	VGNC	VGNC:34159
Felis catus	RRAGB	VGNC	VGNC:64768
Macaca mulatta	RRAGB	VGNC	VGNC:77059
Rattus norvegicus	RRAGB	RGD	RGD:619805
Canis familiaris	RRAGB	VGNC	VGNC:54187

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