RRAGC - Ras related GTP binding C Gene

Homo sapiens

Also known as GTR2; RAGC; TIB929

Gene ID: 64121 | Gene type: protein coding

About RRAGC

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:38,838,198-38,859,772 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 23.8), placenta (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

RRAGC Products(2)

mRNA	Protein	Name
NM_001271851.2	NP_001258780.1	ras-related GTP-binding protein C isoform 2
NM_022157.4	NP_071440.1	ras-related GTP-binding protein C isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	11073942	GOA
enables GDP binding	IMP IMP: Inferred from mutant phenotype	22424946	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	11073942	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	22424946	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	11073942	GOA
enables GTPase binding	IPI IPI: Inferred from physical interaction	22424946	GOA
enables enzyme-substrate adaptor activity	IDA IDA: Inferred from direct assay	32612235	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	32612235	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11073942	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11073942	GOA
enables protein-membrane adaptor activity	IDA IDA: Inferred from direct assay	31601708	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid starvation	IGI IGI: Inferred from genetic interaction	23723238	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	31601708	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	31601708	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	26691987	GOA
involved in protein localization to lysosome	IDA IDA: Inferred from direct assay	31601708	GOA
involved in protein localization to membrane	IDA IDA: Inferred from direct assay	31601708	GOA
involved in regulation of TOR signaling	IGI IGI: Inferred from genetic interaction	23723238	GOA
involved in regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	27222292	GOA
involved in response to amino acid	IMP IMP: Inferred from mutant phenotype	27222292	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FNIP-folliculin RagC/D GAP	IDA IDA: Inferred from direct assay	32612235	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11073942	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	31601708	GOA
located in lysosome	IDA IDA: Inferred from direct assay	20381137	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11073942	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRAGC Protein Structure

Gtr1_RagA

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

ras-related GTP-binding protein C

GTPase-interacting protein 2

RRAGC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RRAGC	Q9HB90	NSL1	Homo sapiens	Q96IY1	Lumier	37398436
Intra	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	BRET	37398436
Intra	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	22424946
Intra	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	BiLC	37398436
Intra	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	Affinity Chrom	22980980
Intra	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	25561175
Intra	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	25567906
Intra	RRAGC	Q9HB90	RRAGA	Homo sapiens	Q7L523	Y2H	11073942
Intra	RRAGC	Q9HB90	RRAGA	Homo sapiens	Q7L523	Anti Tag CoIP	11073942
Intra	RRAGC	Q9HB90	RRAGA	Homo sapiens	Q7L523	Pull Down	11073942
Intra	RRAGC	Q9HB90	RRAGB	Homo sapiens	Q5VZM2	Anti Bait CoIP	20381137
Intra	RRAGC	Q9HB90	RRAGB	Homo sapiens	Q5VZM2	Anti Tag CoIP	22424946
Intra	RRAGC	Q9HB90	RRAGB	Homo sapiens	Q5VZM2	Anti Tag CoIP	25561175
Intra	RRAGC	Q9HB90	RRAGB	Homo sapiens	Q5VZM2	Anti Tag CoIP	25567906
Intra	RRAGC	Q9HB90	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25567906
Intra	RRAGC	Q9HB90	SLC38A9	Homo sapiens	Q8NBW4	Anti Bait CoIP	25567906
Intra	RRAGC	Q9HB90	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25561175

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome	Fibrofolliculomas With Trichodiscomas And Acrochordons
BHD	Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculoma Familial	Bhd Syndrome
Birt Hogg Dube Syndrome	Hornstein-Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculomas

Retinitis Pigmentosa 60

RP60	Retinitis Pigmentosa, Type 60

Familial Renal Oncocytoma

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C	FANCC
Facc	Fac
Fa3	Fanconi Pancytopenia Type 3
Fanconi Pancytopenia, Type 3	Faces Syndrome
Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies	Friedman-Goodman Syndrome
Abnormality Of The Face

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12278	RRAGC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RRAGC	VGNC	VGNC:45756
Mus musculus	RRAGC	MGD	MGI:1858751
Rattus norvegicus	RRAGC	RGD	RGD:1311760
Bos taurus	RRAGC	VGNC	VGNC:34160
Macaca mulatta	RRAGC	VGNC	VGNC:77060
Felis catus	RRAGC	VGNC	VGNC:64769

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