2. Gene
  3. SLC38A9 - solute carrier family 38 member 9 Gene

SLC38A9 - solute carrier family 38 member 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SNAT9; URLC11

Gene ID: 153129 | Gene type: protein coding

About SLC38A9

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,625,845-55,712,335 (from NCBI)

This gene has 26 transcripts (splice variants), 209 orthologues and 15 paralogues. Broad expression in placenta (RPKM 15.1), testis (RPKM 7.5) and 22 other tissues.

Summary

Enables L-arginine transmembrane transporter activity and L-leucine transmembrane transporter activity. Involved in amino acid transmembrane transport; cellular response to amino acid stimulus; and positive regulation of TOR signaling. Located in late endosome and lysosomal membrane. Is integral component of lysosomal membrane. Colocalizes with Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]

SLC38A9 Products(8)

mRNA Protein Name
NM_001258286.1 NP_001245215.1 sodium-coupled neutral amino acid transporter 9 isoform 2
NM_001258287.1 NP_001245216.1 sodium-coupled neutral amino acid transporter 9 isoform 3
NM_001282429.1 NP_001269358.1 sodium-coupled neutral amino acid transporter 9 isoform 4
NM_001349382.1 NP_001336311.1 sodium-coupled neutral amino acid transporter 9 isoform 1
NM_001349383.1 NP_001336312.1 sodium-coupled neutral amino acid transporter 9 isoform 1
NM_001349384.1 NP_001336313.1 sodium-coupled neutral amino acid transporter 9 isoform 1
NM_001349385.1 NP_001336314.1 sodium-coupled neutral amino acid transporter 9 isoform 5
NM_173514.4 NP_775785.2 sodium-coupled neutral amino acid transporter 9 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-arginine transmembrane transporter activity IDA
IDA: Inferred from direct assay
25567906 GOA
enables L-asparagine transmembrane transporter activity IDA
IDA: Inferred from direct assay
25561175 GOA
enables L-glutamine transmembrane transporter activity IDA
IDA: Inferred from direct assay
25561175 GOA
enables L-leucine transmembrane transporter activity IDA
IDA: Inferred from direct assay
29053970 GOA
enables amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
25561175 GOA
enables cholesterol binding IDA
IDA: Inferred from direct assay
28336668 GOA
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
30181260 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25561175 GOA
enables sterol sensor activity IDA
IDA: Inferred from direct assay
28336668 GOA
Biological Process GO Annotation Evidence Reference Source
involved in L-arginine transmembrane transport IDA
IDA: Inferred from direct assay
25567906 GOA
involved in amino acid transmembrane transport IDA
IDA: Inferred from direct assay
25567906 GOA
involved in asparagine transport IDA
IDA: Inferred from direct assay
25561175 GOA
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
25561175 GOA
involved in glutamine transport IDA
IDA: Inferred from direct assay
25561175 GOA
involved in positive regulation of TOR signaling IDA
IDA: Inferred from direct assay
25561175 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
28336668 GOA
Cellular Component GO Annotation Evidence Reference Source
part of FNIP-folliculin RagC/D GAP IDA
IDA: Inferred from direct assay
36103527 GOA
part of Ragulator complex IDA
IDA: Inferred from direct assay
25561175 GOA
located in late endosome IDA
IDA: Inferred from direct assay
25561175 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
30956113 GOA
located in lysosomal membrane IMP
IMP: Inferred from mutant phenotype
29053970 GOA
located in lysosome IDA
IDA: Inferred from direct assay
25561175 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC38A9 Protein Structure

Aa_trans

Aa_trans: Transmembrane amino acid transporter protein (119 - 239)

Aa_trans

Aa_trans: Transmembrane amino acid transporter protein (299 - 557)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 561 a.a.
Protein Preferred Names Protein Names

sodium-coupled neutral amino acid transporter 9

putative sodium-coupled neutral amino acid transporter 9

SLC38A9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC38A9 Q8NBW4 LAMTOR3 Homo sapiens Q9UHA4
Anti Tag CoIP
25561175
Intra
SLC38A9 Q8NBW4 LAMTOR2 Homo sapiens Q9Y2Q5
Anti Tag CoIP
25567906
Intra
SLC38A9 Q8NBW4 LAMTOR2 Homo sapiens Q9Y2Q5
Anti Tag CoIP
25561175
Intra
SLC38A9 Q8NBW4 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
25567906
Intra
SLC38A9 Q8NBW4 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
25561175
Intra
SLC38A9 Q8NBW4 LAMTOR5 Homo sapiens O43504
Anti Tag CoIP
25561175
Intra
SLC38A9 Q8NBW4 LAMTOR5 Homo sapiens O43504
Anti Tag CoIP
25567906
Intra
SLC38A9 Q8NBW4 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25561175
Intra
SLC38A9 Q8NBW4 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25567906
Intra
SLC38A9 Q8NBW4 LAMTOR1 Homo sapiens Q6IAA8
Anti Bait CoIP
25561175
Intra
SLC38A9 Q8NBW4 RRAGA Homo sapiens Q7L523
Anti Bait CoIP
25561175
Intra
SLC38A9 Q8NBW4 RRAGA Homo sapiens Q7L523
Anti Tag CoIP
25561175
Intra
SLC38A9 Q8NBW4 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
25561175
Intra
SLC38A9 Q8NBW4 RRAGB Homo sapiens Q5VZM2
Anti Tag CoIP
25561175
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukodystrophy, Hypomyelinating, 3

Hypomyelinating Leukodystrophy 3

HLD3

Pelizaeus-Merzbacher-Like Disease Due To Aimp1 Mutation

Leukodystrophy, Hypomyelinating 3

Perinatal Sudanophilic Leukodystrophy

Leukodystrophy, Hypomyelinating, Type 3

Pelizaeus-Merzbacher-Like Disease, Autosomal Recessive, 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13227 SLC38A9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC38A9 MGD MGI:1918839
Felis catus SLC38A9 VGNC VGNC:65352
Bos taurus SLC38A9 VGNC VGNC:34856
Canis familiaris SLC38A9 VGNC VGNC:46399
Rattus norvegicus SLC38A9 RGD RGD:1311881
Macaca mulatta SLC38A9 VGNC VGNC:77574