RRAGD - Ras related GTP binding D Gene

Homo sapiens

Also known as RAGD; HOMG7; bA11D8.2.1

Gene ID: 58528 | Gene type: protein coding

About RRAGD

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,364,616-89,412,273 (from NCBI)

This gene has 3 transcripts (splice variants), 186 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 16.9), heart (RPKM 13.1) and 20 other tissues.

Summary

RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]

RRAGD Products(1)

mRNA	Protein	Name
NM_021244.5	NP_067067.1	ras-related GTP-binding protein D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	32612235	GOA
enables GDP binding	IMP IMP: Inferred from mutant phenotype	22424946	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	22424946	GOA
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	22424946	GOA
enables GTPase binding	IPI IPI: Inferred from physical interaction	22424946	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	32612235	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11073942	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11073942	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to L-leucine	IMP IMP: Inferred from mutant phenotype	22424946	GOA
involved in cellular response to leucine starvation	IMP IMP: Inferred from mutant phenotype	22424946	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	22424946	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11073942	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	34607910	GOA
located in lysosome	IDA IDA: Inferred from direct assay	20381137	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11073942	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	34607910	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRAGD Protein Structure

Gtr1_RagA

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

ras-related GTP-binding protein D

Rag D protein

RRAGD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RRAGD	Q9NQL2	LARS1	Homo sapiens	Q9P2J5	Pull Down	22424946
Intra	RRAGD	Q9NQL2	LARS1	Homo sapiens	Q9P2J5	Anti Tag CoIP	22424946
Intra	RRAGD	Q9NQL2	LARS1	Homo sapiens	Q9P2J5	IF	22424946
Intra	RRAGD	Q9NQL2	RRAGA	Homo sapiens	Q7L523	Anti Tag CoIP	22424946
Intra	RRAGD	Q9NQL2	RRAGA	Homo sapiens	Q7L523	Anti Tag CoIP	11073942
Intra	RRAGD	Q9NQL2	RRAGB	Homo sapiens	Q5VZM2	Anti Tag CoIP	22424946
Intra	RRAGD	Q9NQL2	RRAGB	Homo sapiens	Q5VZM2	Anti Tag CoIP	11073942

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome	Fibrofolliculomas With Trichodiscomas And Acrochordons
BHD	Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculoma Familial	Bhd Syndrome
Birt Hogg Dube Syndrome	Hornstein-Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12279	RRAGD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RRAGD	MGD	MGI:1098604
Rattus norvegicus	RRAGD	RGD	RGD:1310007
Macaca mulatta	RRAGD	VGNC	VGNC:77061
Felis catus	RRAGD	VGNC	VGNC:64770
Bos taurus	RRAGD	VGNC	VGNC:34161
Canis familiaris	RRAGD	VGNC	VGNC:49747

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