AKR1A1 - aldo-keto reductase family 1 member A1 Gene

Homo sapiens

Also known as ALR; ARM; DD3; ALDR1; HEL-S-6

Gene ID: 10327 | Gene type: protein coding

About AKR1A1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,550,826-45,570,049 (from NCBI)

This gene has 14 transcripts (splice variants), 234 orthologues and 16 paralogues. Ubiquitous expression in kidney (RPKM 113.8), duodenum (RPKM 66.6) and 25 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

AKR1A1 Products(4)

mRNA	Protein	Name
NM_001202413.2	NP_001189342.1	aldo-keto reductase family 1 member A1
NM_001202414.2	NP_001189343.1	aldo-keto reductase family 1 member A1
NM_006066.4	NP_006057.1	aldo-keto reductase family 1 member A1
NM_153326.3	NP_697021.1	aldo-keto reductase family 1 member A1

AKR1A1 Protein Structure

Aldo_ket_red

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

aldo-keto reductase family 1 member A1

HEL-S-165mP

Recombinant AKR1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76137	AKR1A1 Protein, Human (His)	P14550 (M1-Y325)	≥95%

Related Diseases

Diseases

Alias

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders	Arbd
Arnd	Alcohol-Related Birth Defects
Alcohol-Related Neurodevelopmental Disorder	Fas
Fasd	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk
Alcohol Related Birth Defect	Alcohol Related Neurodevelopmental Disorder
Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk
Dysmorphism Due To Alcohol	Fetal Etoh Syndrome

Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis	Portal Cirrhosis
Alcoholic Cirrhosis Of Liver	Liver Cirrhosis, Alcoholic
Laennec'S Cirrhosis	Laennec'S Cirrhosis, Alcoholic
Alcohol Cirrhosis	Alcoholic Laennec Cirrhosis
Alcoholic Cirrhosis Nos	Etoh Cirrhosis
Alcohol Hepatic Cirrhosis	Alcohol Liver Cirrhosis
Laennec Cirrhosis

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Metabolic Acidosis

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106697	Ponalrestat	Inhibitor	99.51%	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0376	Liquiritin		99.68%	Unkown
HY-D1341	Coumberone		99.95%	Unkown
HY-114009	AKR1C1-IN-1		99.38%	Unkown
HY-150644	S07-2010	Inhibitor	99.79%	Unkown
HY-133708	β-Glucogallin	Inhibitor	99.82%	Unkown
HY-113850	CPSA		/	Unkown
HY-149254	PTP1B/AKR1B1-IN-1	Inhibitor	/	Unkown
HY-149255	PTP1B/AKR1B1-IN-2	Inhibitor	/	Unkown
HY-163609	PROTAC AKR1C3 degrader-1	Degrader	/	Unkown
HY-N8549A	5-Dihydrocortisone		≥99.0%	Unkown
HY-RS00531	AKR1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00532	AKR1B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00534	AKR1C1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00538	AKR1D1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-118819	5-Bromo-3-phenyl salicylic acid	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKR1A1	RGD	RGD:68346
Bos taurus	AKR1A1	VGNC	VGNC:25795
Felis catus	AKR1A1	VGNC	VGNC:59723
Mus musculus	AKR1A1	MGD	MGI:1929955
Macaca mulatta	AKR1A1	VGNC	VGNC:106319
Canis familiaris	AKR1A1	VGNC	VGNC:37768
Others	AKR1A1	NCBI

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