2. Gene
  3. AKR1A1 - aldo-keto reductase family 1 member A1 Gene

AKR1A1 - aldo-keto reductase family 1 member A1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ALR; ARM; DD3; ALDR1; HEL-S-6

Gene ID: 10327 | Gene type: protein coding

About AKR1A1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,550,826-45,570,049 (from NCBI)

This gene has 14 transcripts (splice variants), 234 orthologues and 16 paralogues. Ubiquitous expression in kidney (RPKM 113.8), duodenum (RPKM 66.6) and 25 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

AKR1A1 Products(4)

mRNA Protein Name
NM_001202413.2 NP_001189342.1 aldo-keto reductase family 1 member A1
NM_001202414.2 NP_001189343.1 aldo-keto reductase family 1 member A1
NM_006066.4 NP_006057.1 aldo-keto reductase family 1 member A1
NM_153326.3 NP_697021.1 aldo-keto reductase family 1 member A1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables L-glucuronate reductase activity EXP
EXP: Inferred from Experiment
7669785 GOA
enables L-glucuronate reductase activity IDA
IDA: Inferred from direct assay
10510318 GOA
enables glucuronolactone reductase activity IDA
IDA: Inferred from direct assay
10510318 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence Reference Source
involved in daunorubicin metabolic process IDA
IDA: Inferred from direct assay
18276838 GOA
involved in doxorubicin metabolic process IDA
IDA: Inferred from direct assay
18276838 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1A1 Protein Structure

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (17 - 293)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member A1

HEL-S-165mP

Recombinant AKR1A1 Proteins

Cat. No. Product Name Accession Purity
HY-P76137 AKR1A1 Protein, Human (His) P14550 (M1-Y325) ≥95%

Related Diseases

Diseases Alias
Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders

Arbd

Arnd

Alcohol-Related Birth Defects

Alcohol-Related Neurodevelopmental Disorder

Fas

Fasd

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

Alcohol Related Birth Defect

Alcohol Related Neurodevelopmental Disorder

Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

Dysmorphism Due To Alcohol

Fetal Etoh Syndrome
Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis

Portal Cirrhosis

Alcoholic Cirrhosis Of Liver

Liver Cirrhosis, Alcoholic

Laennec'S Cirrhosis

Laennec'S Cirrhosis, Alcoholic

Alcohol Cirrhosis

Alcoholic Laennec Cirrhosis

Alcoholic Cirrhosis Nos

Etoh Cirrhosis

Alcohol Hepatic Cirrhosis

Alcohol Liver Cirrhosis

Laennec Cirrhosis
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Liver Cirrhosis

Cirrhosis

Cirrhosis Of Liver

CIRRH

Cryptogenic Cirrhosis

Cirrhosis, Cryptogenic

Cirrhosis Nos
Metabolic Acidosis
Hypoascorbemia

Scurvy

Ascorbic Acid Deficiency

Vitamin C Deficiency

Vitamin C, Inability To Synthesize

Deficiency Of Vitamin C

Scorbutus

Vitamin C
Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-106697 Ponalrestat Inhibitor 99.51% Phase 3
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0376 Liquiritin 99.68% Unkown
HY-D1341 Coumberone 99.95% Unkown
HY-114009 AKR1C1-IN-1 99.38% Unkown
HY-150644 S07-2010 Inhibitor 99.79% Unkown
HY-133708 β-Glucogallin Inhibitor 99.82% Unkown
HY-113850 CPSA / Unkown
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / Unkown
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / Unkown
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / Unkown
HY-N8549A 5-Dihydrocortisone ≥99.0% Unkown
HY-RS00531 AKR1A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00538 AKR1D1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AKR1A1 RGD RGD:68346
Bos taurus AKR1A1 VGNC VGNC:25795
Felis catus AKR1A1 VGNC VGNC:59723
Mus musculus AKR1A1 MGD MGI:1929955
Macaca mulatta AKR1A1 VGNC VGNC:106319
Canis familiaris AKR1A1 VGNC VGNC:37768
Others AKR1A1 NCBI