NPM2 - nucleophosmin/nucleoplasmin 2 Gene

Homo sapiens

Gene ID: 10361 | Gene type: protein coding

About NPM2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,024,134-22,036,897 (from NCBI)

This gene has 14 transcripts (splice variants), 150 orthologues and 2 paralogues. Biased expression in thyroid (RPKM 3.7), brain (RPKM 3.7) and 12 other tissues.

Summary

Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Involved in several processes, including blastocyst development; oocyte differentiation; and regulation of cell cycle process. Located in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NPM2 Products(12)

mRNA	Protein	Name
NM_001286680.2	NP_001273609.1	nucleoplasmin-2 isoform 1
NM_001286681.2	NP_001273610.1	nucleoplasmin-2 isoform 2
NM_001413113.1	NP_001400042.1	nucleoplasmin-2 isoform 1
NM_001413114.1	NP_001400043.1	nucleoplasmin-2 isoform 3
NM_001413115.1	NP_001400044.1	nucleoplasmin-2 isoform 4
NM_001413116.1	NP_001400045.1	nucleoplasmin-2 isoform 1
NM_001413117.1	NP_001400046.1	nucleoplasmin-2 isoform 5
NM_001413118.1	NP_001400047.1	nucleoplasmin-2 isoform 5
NM_001413119.1	NP_001400048.1	nucleoplasmin-2 isoform 5
NM_001413120.1	NP_001400049.1	nucleoplasmin-2 isoform 4
NM_001413121.1	NP_001400050.1	nucleoplasmin-2 isoform 2
NM_182795.2	NP_877724.1	nucleoplasmin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in blastocyst development	IMP IMP: Inferred from mutant phenotype	12714744	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	12714744	GOA
involved in oocyte differentiation	IEP IEP: Inferred from expression pattern	12714744	GOA
involved in positive regulation of meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	12714744	GOA
involved in regulation of exit from mitosis	IMP IMP: Inferred from mutant phenotype	12714744	GOA
involved in single fertilization	IMP IMP: Inferred from mutant phenotype	12714744	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	12714744	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12714744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPM2 Protein Structure

Nucleoplasmin

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

nucleoplasmin-2

NPM2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NPM2	Q86SE8	NPM3	Homo sapiens	O75607	Y2H Array	31515488
Intra	NPM2	Q86SE8	NPM3	Homo sapiens	O75607	Y2H Prey Pooling	25416956
Intra	NPM2	Q86SE8	NPM3	Homo sapiens	O75607	Anti Tag CoIP	33961781
Intra	NPM2	Q86SE8	NPM3	Homo sapiens	O75607	Y2H Array	25416956
Intra	NPM2	Q86SE8	NPM3	Homo sapiens	O75607	Anti Tag CoIP	28514442
Intra	NPM2	Q86SE8	NPM3	Homo sapiens	O75607	Validated Y2H	25416956
Intra	NPM2	Q86SE8	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	25416956
Intra	NPM2	Q86SE8	SDCBP2	Homo sapiens	Q9H190	Y2H Array	25416956
Intra	NPM2	Q86SE8	SDCBP2	Homo sapiens	Q9H190	Y2H Array	31515488
Intra	NPM2	Q86SE8	NPM1	Homo sapiens	P06748	Validated Y2H	25416956
Intra	NPM2	Q86SE8	NPM1	Homo sapiens	P06748	Anti Tag CoIP	33961781
Intra	NPM2	Q86SE8	NPM1	Homo sapiens	P06748	Y2H Prey Pooling	25416956
Intra	NPM2	Q86SE8	NPM1	Homo sapiens	P06748	Y2H Array	31515488
Intra	NPM2	Q86SE8	NPM1	Homo sapiens	P06748	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09491	NPM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NPM2	VGNC	VGNC:75384
Felis catus	NPM2	VGNC	VGNC:107356
Mus musculus	NPM2	MGD	MGI:1890811
Bos taurus	NPM2	VGNC	VGNC:32207
Rattus norvegicus	NPM2	RGD	RGD:727816

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