CLEC10A - C-type lectin domain containing 10A Gene

Homo sapiens

Also known as HML; MGL; HML2; CD301; CLECSF13; CLECSF14

Gene ID: 10462 | Gene type: protein coding

About CLEC10A

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,074,537-7,080,251 (from NCBI)

This gene has 6 transcripts (splice variants), 148 orthologues and 14 paralogues. Broad expression in appendix (RPKM 13.9), small intestine (RPKM 10.3) and 21 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CLEC10A Products(3)

mRNA	Protein	Name
NM_001330070.2	NP_001316999.1	C-type lectin domain family 10 member A isoform 3
NM_006344.4	NP_006335.2	C-type lectin domain family 10 member A isoform 2
NM_182906.4	NP_878910.1	C-type lectin domain family 10 member A isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC10A Protein Structure

Lectin_N

Lectin_C

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 10 member A

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived)

CLEC10A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLEC10A	Q8IUN9	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	GIMAP1	Homo sapiens	Q8WWP7	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	GIMAP1	Homo sapiens	Q8WWP7	Complementation	32296183
Intra	CLEC10A	Q8IUN9	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	FAM241A	Homo sapiens	Q8N8J7	Anti Tag CoIP	33961781
Cross	CLEC10A	Q8IUN9	S	SARS-CoV-2	P0DTC2	Solution NMR	32915505
Intra	CLEC10A	Q8IUN9	ACSF2	Homo sapiens	Q96CM8	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	NAPB	Homo sapiens	Q9H115	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	FXYD6	Homo sapiens	Q9H0Q3	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	CLEC10A	Q8IUN9	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC10A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72689	CLEC10A/CD301 Protein, Human (HEK293, His)	Q8IUN9 (Q61-H316)	≥95%
HY-P75676	CLEC10A/CD301 Protein, Human (HEK293, Fc)	Q8IUN9-2 (Q61-H292)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02779	CLEC10A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLEC10A	VGNC	VGNC:55799
Rattus norvegicus	CLEC10A	RGD	RGD:621158
Macaca mulatta	CLEC10A	VGNC	VGNC:71188
Mus musculus	CLEC10A	NCBI	NCBI:17312
Others	CLEC10A	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.