2. Gene
  3. NAPB - NSF attachment protein beta Gene

NAPB - NSF attachment protein beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SNAPB; DEE107; SNAP-BETA

Gene ID: 63908 | Gene type: protein coding

About NAPB

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,374,522-23,421,488 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 118.1) and adrenal (RPKM 14.6).

Summary

This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA Receptor. [provided by RefSeq, Mar 2017]

NAPB Products(4)

mRNA Protein Name
NM_001283018.2 NP_001269947.1 beta-soluble NSF attachment protein isoform a
NM_001283020.2 NP_001269949.1 beta-soluble NSF attachment protein isoform c
NM_001283026.2 NP_001269955.1 beta-soluble NSF attachment protein isoform d
NM_022080.3 NP_071363.1 beta-soluble NSF attachment protein isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAPB Protein Structure

SNAP

SNAP: Soluble NSF attachment protein, SNAP (9 - 288)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

beta-soluble NSF attachment protein

N-ethylmaleimide-sensitive factor attachment protein, beta

NAPB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NAPB Q9H115 SNAP23 Homo sapiens A8K287
Validated Y2H
25416956
Intra NAPB Q9H115 SNAP23 Homo sapiens A8K287
Y2H Array
25416956
Intra NAPB Q9H115 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra NAPB Q9H115 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Array
32296183
Intra NAPB Q9H115 STX3 Homo sapiens Q13277
Y2H Array
32296183
Intra NAPB Q9H115 STX3 Homo sapiens Q13277
Validated Y2H
25416956
Intra NAPB Q9H115 STX3 Homo sapiens Q13277
Y2H Array
29892012
Intra NAPB Q9H115 STX3 Homo sapiens Q13277
Y2H Array
31515488
Intra NAPB Q9H115 STX3 Homo sapiens Q13277
Y2H Prey Pooling
25416956
Intra NAPB Q9H115 STX3 Homo sapiens Q13277
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra NAPB Q9H115 KCNN3 Homo sapiens Q9UGI6-2
Validated Y2H
32296183
Intra NAPB Q9H115 KCNN3 Homo sapiens Q9UGI6-2
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra NAPB Q9H115 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra NAPB Q9H115 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 STX6 Homo sapiens O43752
Validated Y2H
25416956
Intra NAPB Q9H115 STX6 Homo sapiens O43752
Y2H
21516116
Intra NAPB Q9H115 STX16 Homo sapiens O14662
Y2H Array
25416956
Intra NAPB Q9H115 STX16 Homo sapiens O14662
Y2H Prey Pooling
25416956
Intra NAPB Q9H115 STX16 Homo sapiens O14662
Validated Y2H
25416956
Intra NAPB Q9H115 CLEC10A Homo sapiens Q8IUN9
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 CLEC10A Homo sapiens Q8IUN9
Y2H Array
32296183
Intra NAPB Q9H115 ALOX5AP Homo sapiens P20292
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 ALOX5AP Homo sapiens P20292
Y2H Array
32296183
Intra NAPB Q9H115 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra NAPB Q9H115 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 TFEC Homo sapiens O14948
Validated Y2H
25416956
Intra NAPB Q9H115 SNAP29 Homo sapiens O95721
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 SNAP29 Homo sapiens O95721
Y2H Array
32296183
Intra NAPB Q9H115 SYT1 Homo sapiens P21579
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 SYT1 Homo sapiens P21579
Y2H Array
32296183
Intra NAPB Q9H115 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra NAPB Q9H115 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 STX5 Homo sapiens Q13190
Y2H Array
25416956
Intra NAPB Q9H115 STX5 Homo sapiens Q13190
Y2H Array
32296183
Intra NAPB Q9H115 STX5 Homo sapiens Q13190
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 STX5 Homo sapiens Q13190
Validated Y2H
25416956
Intra NAPB Q9H115 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
25416956
Intra NAPB Q9H115 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra NAPB Q9H115 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra NAPB Q9H115 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 STX4 Homo sapiens Q12846
Y2H Prey Pooling
25416956
Intra NAPB Q9H115 STX4 Homo sapiens Q12846
Validated Y2H
25416956
Intra NAPB Q9H115 STX4 Homo sapiens Q12846
Y2H Array
25416956
Intra NAPB Q9H115 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra NAPB Q9H115 SNAP23 Homo sapiens O00161
Validated Y2H
25416956
Intra NAPB Q9H115 BET1 Homo sapiens O15155
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 BET1 Homo sapiens O15155
Y2H Array
32296183
Intra NAPB Q9H115 SIGLEC5 Homo sapiens O15389
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 SIGLEC5 Homo sapiens O15389
Y2H Array
32296183
Intra NAPB Q9H115 SYT2 Homo sapiens Q8N9I0
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 SYT2 Homo sapiens Q8N9I0
Y2H Array
32296183
Intra NAPB Q9H115 STX19 Homo sapiens Q8N4C7
Y2H Array
32296183
Intra NAPB Q9H115 STX19 Homo sapiens Q8N4C7
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 PLEKHO1 Homo sapiens Q53GL0
Y2H Prey Pooling
32296183
Intra NAPB Q9H115 PLEKHO1 Homo sapiens Q53GL0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 107

DEE107

Developmental And Epileptic Encephalopathy-107
Amyotrophy, Hereditary Neuralgic

Hereditary Neuralgic Amyotrophy

Neuritis With Brachial Predilection

HNA

Napb

Brachial Plexus Neuropathy, Hereditary

Hereditary Brachial Plexus Neuropathy

Amyotrophy, Hereditary Neuralgic, With Predilection For Brachial Plexus

Brachial Neuralgia

Brachial Plexus Neuritis

Neuralgic Amyotrophy

Amyotrophic Neuralgia

Brachial Neuritis

Familial Brachial Plexus Neuritis

Heredofamilial Neuritis With Brachial Plexus Predilection

Shoulder Girdle Neuropathy

Hereditary Neuralgic Amyotrophy With Predilection For Brachial Plexus

Amyotrophy, Neuralgic, Hereditary

Acute Brachial Neuritis
Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder

Obsessive-Compulsive Personality

Compulsive Personality Disorder

Ocpd

Obsessional Personality Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09030 NAPB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NAPB VGNC VGNC:43620
Mus musculus NAPB MGD MGI:104562
Felis catus NAPB VGNC VGNC:81129
Macaca mulatta NAPB VGNC VGNC:74963
Bos taurus NAPB VGNC VGNC:31882
Rattus norvegicus NAPB RGD RGD:1589649