SLC38A7 - solute carrier family 38 member 7 Gene

Homo sapiens

Also known as SNAT7

Gene ID: 55238 | Gene type: protein coding

About SLC38A7

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,665,109-58,684,770 (from NCBI)

This gene has 16 transcripts (splice variants), 242 orthologues and 15 paralogues. Broad expression in testis (RPKM 12.2), brain (RPKM 4.6) and 23 other tissues.

Summary

Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and sodium ion transport. Predicted to be located in axon and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]

SLC38A7 Products(6)

mRNA	Protein	Name
NM_001308384.2	NP_001295313.1	putative sodium-coupled neutral amino acid transporter 7 isoform 2
NM_001369608.1	NP_001356537.1	putative sodium-coupled neutral amino acid transporter 7 isoform 1
NM_001369609.1	NP_001356538.1	putative sodium-coupled neutral amino acid transporter 7 isoform 1
NM_001369610.1	NP_001356539.1	putative sodium-coupled neutral amino acid transporter 7 isoform 2
NM_001369611.1	NP_001356540.1	putative sodium-coupled neutral amino acid transporter 7 isoform 1
NM_018231.3	NP_060701.1	putative sodium-coupled neutral amino acid transporter 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-asparagine:sodium symporter activity	IDA IDA: Inferred from direct assay	28416685	GOA
enables L-glutamine:sodium symporter activity	IDA IDA: Inferred from direct assay	28416685	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in asparagine transport	IDA IDA: Inferred from direct assay	28416685	GOA
involved in glutamine transport	IDA IDA: Inferred from direct assay	28416685	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosomal membrane	IDA IDA: Inferred from direct assay	35561222	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC38A7 Protein Structure

Aa_trans

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

putative sodium-coupled neutral amino acid transporter 7

Sodium-coupled neutral amino acid transporter 7

SLC38A7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC38A7	Q9NVC3	IL10RA	Homo sapiens	Q13651	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	IL10RA	Homo sapiens	Q13651	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	LYVE1	Homo sapiens	Q9Y5Y7	Validated Y2H	32296183
Intra	SLC38A7	Q9NVC3	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	ACBD5	Homo sapiens	Q5T8D3-2	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	ACBD5	Homo sapiens	Q5T8D3-2	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SLC6A15	Homo sapiens	Q9H2J7	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SLC6A15	Homo sapiens	Q9H2J7	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	ODF4	Homo sapiens	Q2M2E3	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	ODF4	Homo sapiens	Q2M2E3	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	AQP2	Homo sapiens	P41181	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	AQP2	Homo sapiens	P41181	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	PDCD1LG2	Homo sapiens	Q9BQ51	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	SLC38A7	Q9NVC3	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	AQP9	Homo sapiens	O43315	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	AQP9	Homo sapiens	O43315	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	BTNL9	Homo sapiens	Q6UXG8-3	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SYPL2	Homo sapiens	Q5VXT5-2	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	SYPL2	Homo sapiens	Q5VXT5-2	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	APH1A	Homo sapiens	Q96BI3	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	APH1A	Homo sapiens	Q96BI3	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	HHLA2	Homo sapiens	Q9UM44	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	HHLA2	Homo sapiens	Q9UM44	Validated Y2H	32296183
Intra	SLC38A7	Q9NVC3	HHLA2	Homo sapiens	Q9UM44	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	CLEC10A	Homo sapiens	Q8IUN9	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	CLEC10A	Homo sapiens	Q8IUN9	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	RNF5	Homo sapiens	Q99942	Y2H Array	25416956
Intra	SLC38A7	Q9NVC3	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	25416956
Intra	SLC38A7	Q9NVC3	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	SLC38A7	Q9NVC3	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	TSPAN8	Homo sapiens	P19075	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	TSPAN8	Homo sapiens	P19075	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	EDA	Homo sapiens	Q92838	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	PANX1	Homo sapiens	Q96RD7	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	PANX1	Homo sapiens	Q96RD7	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	YIPF6	Homo sapiens	Q96EC8	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	YIPF6	Homo sapiens	Q96EC8	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SLC38A7	Q9NVC3	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	CREB3L3	Homo sapiens	Q68CJ9	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	CREB3L3	Homo sapiens	Q68CJ9	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	SLC30A2	Homo sapiens	Q9BRI3	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	SLC30A2	Homo sapiens	Q9BRI3	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	LY6G6C	Homo sapiens	O95867	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	LY6G6C	Homo sapiens	O95867	Y2H Array	32296183
Intra	SLC38A7	Q9NVC3	ERP29	Homo sapiens	P30040	Y2H Prey Pooling	32296183
Intra	SLC38A7	Q9NVC3	ERP29	Homo sapiens	P30040	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Triple-Receptor Negative Breast Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13225	SLC38A7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC38A7	VGNC	VGNC:34854
Felis catus	SLC38A7	VGNC	VGNC:65350
Macaca mulatta	SLC38A7	VGNC	VGNC:77570
Mus musculus	SLC38A7	MGD	MGI:2679005
Rattus norvegicus	SLC38A7	RGD	RGD:1303268
Canis familiaris	SLC38A7	VGNC	VGNC:46397

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