2. Gene
  3. PPIH - peptidylprolyl isomerase H Gene

PPIH - peptidylprolyl isomerase H Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CYPH; CYP-20; USA-CYP; SnuCyp-20

Gene ID: 10465 | Gene type: protein coding

About PPIH

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,658,423-42,681,654 (from NCBI)

This gene has 20 transcripts (splice variants), 207 orthologues and 22 paralogues. Ubiquitous expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]

PPIH Products(2)

mRNA Protein Name
NM_001330510.2 NP_001317439.1 peptidyl-prolyl cis-trans isomerase H isoform 2
NM_006347.4 NP_006338.1 peptidyl-prolyl cis-trans isomerase H isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
9570313 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9570313 GOA
enables ribonucleoprotein complex binding IDA
IDA: Inferred from direct assay
9570313 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of viral genome replication IMP
IMP: Inferred from mutant phenotype
19932913 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U4/U6 snRNP IDA
IDA: Inferred from direct assay
9570313 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: Inferred from direct assay
9570313 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9570313 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
9570313 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIH Protein Structure

Pro_isomerase

Pro_isomerase: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (15 - 175)

  • 0
  • 100
  • 177 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase H

PPIase h

PPIH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PPIH O43447 DOK3 Homo sapiens Q7L591-3
Validated Y2H
32296183
Intra
PPIH O43447 DOK3 Homo sapiens Q7L591-3
Y2H Array
32296183
Intra
PPIH O43447 DOK3 Homo sapiens Q7L591-3
Y2H Prey Pooling
32296183
Intra
PPIH O43447 N4BP2L2 Homo sapiens Q92802
Y2H Prey Pooling
25416956
Intra
PPIH O43447 N4BP2L2 Homo sapiens Q92802
Validated Y2H
25416956
Intra
PPIH O43447 N4BP2L2 Homo sapiens Q92802
Y2H Prey Pooling
32296183
Intra
PPIH O43447 N4BP2L2 Homo sapiens Q92802
Validated Y2H
32296183
Intra
PPIH O43447 N4BP2L2 Homo sapiens Q92802
Y2H Array
32296183
Cross
PPIH O43447 P0C6X7-PRO_0000037309 Human SARS coronavirus P0C6X7-PRO_0000037309
Lumier
22046132
Cross
PPIH O43447 P0C6X7-PRO_0000037309 Human SARS coronavirus P0C6X7-PRO_0000037309
Y2H Pooling
22046132
Intra
PPIH O43447 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra
PPIH O43447 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
PPIH O43447 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
PPIH O43447 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
PPIH O43447 XIAP Homo sapiens P98170
BFG-2H
27107012
Intra
PPIH O43447 XIAP Homo sapiens P98170
Y2H Array
32296183
Intra
PPIH O43447 XIAP Homo sapiens P98170
Validated Y2H
27107012
Intra
PPIH O43447 XIAP Homo sapiens P98170
Y2H Prey Pooling
32296183
Intra
PPIH O43447 XIAP Homo sapiens P98170
Validated Y2H
32296183
Intra
PPIH O43447 PRPF4 Homo sapiens O43172
Y2H
22365833
Intra
PPIH O43447 PRPF4 Homo sapiens O43172
Y2H
16723661
Intra
PPIH O43447 PRPF4 Homo sapiens O43172
Pull Down
12907720
Intra
PPIH O43447 PRPF4 Homo sapiens O43172
X-Ray Diffraction
12875835
Intra
PPIH O43447 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
PPIH O43447 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
PPIH O43447 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
PPIH O43447 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra
PPIH O43447 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
Intra
PPIH O43447 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra
PPIH O43447 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
PPIH O43447 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
PPIH O43447 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
PPIH O43447 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Intra
PPIH O43447 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra
PPIH O43447 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIH Proteins

Cat. No. Product Name Accession Purity
HY-P71029 PPIH Protein, Human (His) O43447-1 (M1-M177) ≥95%

Related Diseases

Diseases Alias
Myxosarcoma
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10953 PPIH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPIH VGNC VGNC:33200
Canis familiaris PPIH VGNC VGNC:44854
Mus musculus PPIH MGD MGI:106499
Felis catus PPIH VGNC VGNC:80316
Rattus norvegicus PPIH RGD RGD:1564921
Macaca mulatta PPIH VGNC VGNC:103846
Others PPIH NCBI