ANP32B - acidic nuclear phosphoprotein 32 family member B Gene

Homo sapiens

Also known as APRIL; SSP29; PHAPI2

Gene ID: 10541 | Gene type: protein coding

About ANP32B

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,983,341-98,015,943 (from NCBI)

This gene has 3 transcripts (splice variants), 302 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 88.8), lymph node (RPKM 73.8) and 25 other tissues.

Summary

Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleoplasm. Colocalizes with nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

ANP32B Products(1)

mRNA	Protein	Name
NM_006401.3	NP_006392.1	acidic leucine-rich nuclear phosphoprotein 32 family member B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase binding	IDA IDA: Inferred from direct assay	9285060	GOA
enables histone binding	IDA IDA: Inferred from direct assay	20538007	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	20015864	GOA
involved in negative regulation of cell differentiation	IDA IDA: Inferred from direct assay	22705300	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	20538007	GOA
involved in positive regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	17178712	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17178712	GOA
colocalizes with nucleolus	IDA IDA: Inferred from direct assay	9285060	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9285060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANP32B Protein Structure

LRR_9

0
100
200
251 a.a.

Protein Preferred Names

Protein Names

acidic leucine-rich nuclear phosphoprotein 32 family member B

acidic (leucine-rich) nuclear phosphoprotein 32 family, member B

Related Diseases

Diseases

Alias

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Myopathy, Congenital, Compton-North

Compton-North Congenital Myopathy	MYPCN
Congenital Lethal Myopathy, Compton-North Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00752	ANP32B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ANP32B	VGNC	VGNC:59835
Rattus norvegicus	ANP32B	RGD	RGD:621285
Macaca mulatta	ANP32B	VGNC	VGNC:103240
Canis familiaris	ANP32B	VGNC	VGNC:37933
Bos taurus	ANP32B	VGNC	VGNC:25958
Mus musculus	ANP32B	MGD	MGI:1914878

Name
Email *

	Sorry, but the email address you supplied was invalid.