2. Gene
  3. KPNA5 - karyopherin subunit alpha 5 Gene

KPNA5 - karyopherin subunit alpha 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SRP6; IPOA6

Gene ID: 3841 | Gene type: protein coding

About KPNA5

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:116,681,211-116,741,867 (from NCBI)

This gene has 7 transcripts (splice variants), 184 orthologues and 6 paralogues. Broad expression in testis (RPKM 10.4), ovary (RPKM 8.3) and 24 other tissues.

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

KPNA5 Products(8)

mRNA Protein Name
NM_001366304.1 NP_001353233.1 importin subunit alpha-6 isoform a
NM_001366305.2 NP_001353234.1 importin subunit alpha-6 isoform a
NM_001366306.2 NP_001353235.1 importin subunit alpha-6 isoform b
NM_001366307.2 NP_001353236.1 importin subunit alpha-6 isoform c
NM_001366308.1 NP_001353237.1 importin subunit alpha-6 isoform d
NM_001366309.2 NP_001353238.1 importin subunit alpha-6 isoform e
NM_001366310.2 NP_001353239.1 importin subunit alpha-6 isoform f
NM_002269.3 NP_002260.2 importin subunit alpha-6 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15057270 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA5 Protein Structure

IBB

IBB: Importin beta binding domain (6 - 96)

Arm

Arm: Armadillo/beta-catenin-like repeat (116 - 157)

Arm

Arm: Armadillo/beta-catenin-like repeat (163 - 198)

Arm

Arm: Armadillo/beta-catenin-like repeat (201 - 242)

Arm

Arm: Armadillo/beta-catenin-like repeat (256 - 284)

Arm

Arm: Armadillo/beta-catenin-like repeat (287 - 325)

Arm

Arm: Armadillo/beta-catenin-like repeat (331 - 368)

Arm

Arm: Armadillo/beta-catenin-like repeat (370 - 409)

Arm

Arm: Armadillo/beta-catenin-like repeat (413 - 452)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 539 a.a.
Protein Preferred Names Protein Names

importin subunit alpha-6

importin alpha 6

KPNA5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KPNA5 O15131 NRF1 Homo sapiens Q16656-4
Validated Y2H
32296183
Intra
KPNA5 O15131 POU6F2 Homo sapiens P78424
Validated Y2H
32296183
Intra
KPNA5 O15131 NUP50 Homo sapiens Q9UKX7
Validated Y2H
25416956
Intra
KPNA5 O15131 NUP50 Homo sapiens Q9UKX7
Validated Y2H
32296183
Intra
KPNA5 O15131 NUP50 Homo sapiens Q9UKX7
Y2H Prey Pooling
25416956
Intra
KPNA5 O15131 TSEN54 Homo sapiens Q7Z6J9
Validated Y2H
32296183
Intra
KPNA5 O15131 ZNF326 Homo sapiens Q5BKZ1
Validated Y2H
32296183
Intra
KPNA5 O15131 SPOPL Homo sapiens Q6IQ16
Anti Tag CoIP
33961781
Intra
KPNA5 O15131 SPOPL Homo sapiens Q6IQ16
Y2H Array
25416956
Intra
KPNA5 O15131 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra
KPNA5 O15131 HNRNPC Homo sapiens P07910
Validated Y2H
32296183
Intra
KPNA5 O15131 DCPS Homo sapiens Q96C86
Validated Y2H
32296183
Intra
KPNA5 O15131 NMNAT1 Homo sapiens Q9HAN9
Validated Y2H
32296183
Intra
KPNA5 O15131 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
KPNA5 O15131 CDKN1B Homo sapiens P46527
Anti Tag CoIP
22770219
Intra
KPNA5 O15131 CDKN1B Homo sapiens P46527
Pull Down
15057270
Intra
KPNA5 O15131 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra
KPNA5 O15131 RAD52 Homo sapiens P43351
Validated Y2H
32296183
Intra
KPNA5 O15131 MLH1 Homo sapiens P40692
Validated Y2H
32296183
Intra
KPNA5 O15131 ATOSB Homo sapiens Q7L5A3
Validated Y2H
32296183
Intra
KPNA5 O15131 ANP32B Homo sapiens Q92688
Y2H Prey Pooling
25416956
Intra
KPNA5 O15131 ANP32B Homo sapiens Q92688
Validated Y2H
25416956
Intra
KPNA5 O15131 ANP32B Homo sapiens Q92688
Validated Y2H
32296183
Intra
KPNA5 O15131 ANP32B Homo sapiens Q92688
Y2H Array
25416956
Intra
KPNA5 O15131 LMNB1 Homo sapiens P20700
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1

Digitotalar Dysmorphism

DA1A

Da1

Amcd1

Arthrogryposis, Distal, Type 2b4

Distal Arthrogryposis Type 1a

Arthrogryposis, Distal, Type 1

Arthrogryposis Multiplex Congenita Distal Type 1

Arthrogryposis Multiplex Congenita, Distal Type 1

Arthrogryposis Multiplex Congenita, Distal, Type I

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1a

Amc

Arthrogryposis Multiplex Congenita

Arthrogryposis, Distal, 2b4

DA2B4

Arthrogryposis Multiplex Congenita, Distal, Type 1

Arthrogryposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07419 KPNA5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KPNA5 VGNC VGNC:30704
Canis familiaris KPNA5 VGNC VGNC:42503
Rattus norvegicus KPNA5 RGD RGD:1561324
Felis catus KPNA5 VGNC VGNC:67977
Macaca mulatta KPNA5 VGNC VGNC:81085