2. Gene
  3. KPNA6 - karyopherin subunit alpha 6 Gene

KPNA6 - karyopherin subunit alpha 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IPOA7

Gene ID: 23633 | Gene type: protein coding

About KPNA6

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:32,108,056-32,176,563 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 11.5), brain (RPKM 9.1) and 25 other tissues.

Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

KPNA6 Products(1)

mRNA Protein Name
NM_012316.5 NP_036448.1 importin subunit alpha-7
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10523667 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin IMP
IMP: Inferred from mutant phenotype
28189564 GOA
acts upstream of or within positive regulation of viral life cycle IMP
IMP: Inferred from mutant phenotype
28189564 GOA
Cellular Component GO Annotation Evidence Reference Source
part of NLS-dependent protein nuclear import complex IPI
IPI: Inferred from physical interaction
10523667 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA6 Protein Structure

IBB

IBB: Importin beta binding domain (6 - 102)

Arm

Arm: Armadillo/beta-catenin-like repeat (113 - 154)

Arm

Arm: Armadillo/beta-catenin-like repeat (157 - 195)

Arm

Arm: Armadillo/beta-catenin-like repeat (199 - 239)

Arm

Arm: Armadillo/beta-catenin-like repeat (251 - 281)

Arm

Arm: Armadillo/beta-catenin-like repeat (284 - 322)

Arm

Arm: Armadillo/beta-catenin-like repeat (328 - 365)

Arm

Arm: Armadillo/beta-catenin-like repeat (367 - 406)

Arm

Arm: Armadillo/beta-catenin-like repeat (410 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 536 a.a.
Protein Preferred Names Protein Names

importin subunit alpha-7

importin alpha 7 subunit

Related Diseases

Diseases Alias
Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07420 KPNA6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KPNA6 VGNC VGNC:74202
Rattus norvegicus KPNA6 RGD RGD:1306570
Bos taurus KPNA6 VGNC VGNC:30705
Canis familiaris KPNA6 VGNC VGNC:42504
Mus musculus KPNA6 MGD MGI:1100836
Felis catus KPNA6 VGNC VGNC:67978