PAIP1 - poly(A) binding protein interacting protein 1 Gene

Homo sapiens

Gene ID: 10605 | Gene type: protein coding

About PAIP1

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:43,526,267-43,557,411 (from NCBI)

This gene has 10 transcripts (splice variants), 225 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 24.5), thyroid (RPKM 20.8) and 25 other tissues.

Summary

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

PAIP1 Products(3)

mRNA	Protein	Name
NM_006451.5	NP_006442.2	polyadenylate-binding protein-interacting protein 1 isoform 1
NM_182789.4	NP_877590.1	polyadenylate-binding protein-interacting protein 1 isoform 2
NM_183323.3	NP_899152.1	polyadenylate-binding protein-interacting protein 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9548260	GOA
enables translation activator activity	IDA IDA: Inferred from direct assay	9548260	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CRD-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	11051545	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	11051545	GOA
involved in positive regulation by host of viral process	IDA IDA: Inferred from direct assay	33876849	GOA
involved in positive regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	11051545	GOA
acts upstream of positive effect viral translation	IDA IDA: Inferred from direct assay	33876849	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	33876849	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11051545	GOA
part of mCRD-mediated mRNA stability complex	IPI IPI: Inferred from physical interaction	11051545	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAIP1 Protein Structure

PAM2

MIF4G

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

polyadenylate-binding protein-interacting protein 1

PABC1-interacting protein 1

PAIP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	SPR	14685257
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	Y2H	9548260
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	ITC	14685257
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	CoIP	9548260
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	35271311
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	Pull Down	11997512
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	11051545
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	Pull Down	24396066
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	Experimental Interac	9548260
Intra	PAIP1	Q9H074	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09981	PAIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PAIP1	MGD	MGI:2384993
Macaca mulatta	PAIP1	VGNC	VGNC:84476
Rattus norvegicus	PAIP1	RGD	RGD:1305668

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