KIF2C - kinesin family member 2C Gene

Homo sapiens

Also known as MCAK; CT139; KNSL6

Gene ID: 11004 | Gene type: protein coding

About KIF2C

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,739,837-44,767,767 (from NCBI)

This gene has 8 transcripts (splice variants), 127 orthologues and 41 paralogues. Biased expression in testis (RPKM 39.1), bone marrow (RPKM 9.5) and 6 other tissues.

Summary

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

KIF2C Products(4)

mRNA	Protein	Name
NM_001297655.2	NP_001284584.1	kinesin-like protein KIF2C isoform 2
NM_001297656.2	NP_001284585.1	kinesin-like protein KIF2C isoform 3
NM_001297657.2	NP_001284586.1	kinesin-like protein KIF2C isoform 4
NM_006845.4	NP_006836.2	kinesin-like protein KIF2C isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	19632184	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11092768	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in attachment of mitotic spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	23891108	GOA
involved in establishment or maintenance of microtubule cytoskeleton polarity	IMP IMP: Inferred from mutant phenotype	14718566	GOA
involved in metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	23891108	GOA
involved in microtubule depolymerization	IDA IDA: Inferred from direct assay	21820309	GOA
involved in microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	19060894	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in regulation of chromosome segregation	IMP IMP: Inferred from mutant phenotype	19060894	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	14960279	GOA
colocalizes with kinetochore	IDA IDA: Inferred from direct assay	14960279	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	23891108	GOA
located in microtubule plus-end	IDA IDA: Inferred from direct assay	21820309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF2C Protein Structure

Kinesin

0
200
400
600
725 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF2C

kinesin-like protein 6

KIF2C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KIF2C	Q99661	MAPRE1	Homo sapiens	Q15691	Pull Down	19632184
Intra	KIF2C	Q99661	MAPRE1	Homo sapiens	Q15691	Pull Down	19543227
Intra	KIF2C	Q99661	MTUS2	Homo sapiens	Q5JR59	IF	19543227
Intra	KIF2C	Q99661	MTUS2	Homo sapiens	Q5JR59	Pull Down	19543227
Intra	KIF2C	Q99661	SGF29	Homo sapiens	Q96ES7	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07284	KIF2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KIF2C	VGNC	VGNC:30601
Felis catus	KIF2C	VGNC	VGNC:67974
Mus musculus	KIF2C	MGD	MGI:1921054
Macaca mulatta	KIF2C	VGNC	VGNC:74034
Rattus norvegicus	KIF2C	RGD	RGD:620239
Canis familiaris	KIF2C	VGNC	VGNC:42403

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