DSTN - destrin, actin depolymerizing factor Gene

Homo sapiens

Also known as ADF; ACTDP; HEL32; bA462D18.2

Gene ID: 11034 | Gene type: protein coding

About DSTN

Cytogenetic location: 20p12.1 Genomic coordinates (GRCh38): 20:17,570,075-17,609,919 (from NCBI)

This gene has 3 transcripts (splice variants), 127 orthologues and 2 paralogues. Ubiquitous expression in prostate (RPKM 293.6), esophagus (RPKM 273.4) and 25 other tissues.

Summary

The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

DSTN Products(2)

mRNA	Protein	Name
NM_001011546.2	NP_001011546.1	destrin isoform b
NM_006870.4	NP_006861.1	destrin isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	8399167	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament depolymerization	IDA IDA: Inferred from direct assay	11812157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DSTN Protein Structure

Cofilin_ADF

0
100
165 a.a.

Protein Preferred Names

Protein Names

destrin

actin-depolymerizing factor

DSTN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DSTN	P60981	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	DSTN	P60981	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	DSTN	P60981	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	DSTN	P60981	CFL2	Homo sapiens	Q549N0	Validated Y2H	25416956
Intra	DSTN	P60981	CFL2	Homo sapiens	Q549N0	Y2H Prey Pooling	25416956
Intra	DSTN	P60981	CFL2	Homo sapiens	Q9Y281	Y2H Prey Pooling	32296183
Intra	DSTN	P60981	CFL2	Homo sapiens	Q9Y281	Validated Y2H	32296183
Intra	DSTN	P60981	CFL2	Homo sapiens	Q9Y281	Y2H Array	32296183
Intra	DSTN	P60981	ACTG1	Homo sapiens	P63261	Y2H Prey Pooling	25416956
Intra	DSTN	P60981	ACTG1	Homo sapiens	P63261	Y2H Prey Pooling	32296183
Intra	DSTN	P60981	ACTG1	Homo sapiens	P63261	Validated Y2H	32296183
Intra	DSTN	P60981	ACTG1	Homo sapiens	P63261	Y2H Array	32296183
Intra	DSTN	P60981	ACTG1	Homo sapiens	P63261	MAPPIT	25416956
Intra	DSTN	P60981	ACTB	Homo sapiens	P60709	Y2H Array	31515488
Intra	DSTN	P60981	ACTB	Homo sapiens	P60709	Y2H Prey Pooling	25416956
Intra	DSTN	P60981	ACTB	Homo sapiens	P60709	Validated Y2H	25416956
Intra	DSTN	P60981	ACTB	Homo sapiens	P60709	Y2H Prey Pooling	32296183
Intra	DSTN	P60981	ACTB	Homo sapiens	P60709	Y2H Array	32296183
Intra	DSTN	P60981	ACTB	Homo sapiens	P60709	Y2H Array	29892012
Intra	DSTN	P60981	ACTB	Homo sapiens	P60709	Y2H Pooling	16189514
Intra	DSTN	P60981	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	25416956
Intra	DSTN	P60981	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	DSTN	P60981	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	25416956
Intra	DSTN	P60981	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
Intra	DSTN	P60981	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	DSTN	P60981	PS1TP5BP1	Homo sapiens	Q1KLZ0	Validated Y2H	25416956
Intra	DSTN	P60981	PS1TP5BP1	Homo sapiens	Q1KLZ0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Conjugate Gaze Palsy

Palsy Of Conjugate Gaze	Supranuclear Ocular Palsy
Gaze Palsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04029	DSTN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DSTN	VGNC	VGNC:40111
Mus musculus	DSTN	MGD	MGI:1929270
Macaca mulatta	DSTN	VGNC	VGNC:71841
Bos taurus	DSTN	VGNC	VGNC:28226
Felis catus	DSTN	VGNC	VGNC:80087
Rattus norvegicus	DSTN	RGD	RGD:1588366

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