XPO1 - exportin 1 Gene

Homo sapiens

Also known as emb; CRM1; exp1; CRM-1

Gene ID: 7514 | Gene type: protein coding

About XPO1

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,477,849-61,538,612 (from NCBI)

This gene has 55 transcripts (splice variants), 229 orthologues, 1 paralogue and is associated with 91 phenotypes. Ubiquitous expression in testis (RPKM 38.6), lymph node (RPKM 33.8) and 25 other tissues.

Summary

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]

XPO1 Products(2)

mRNA	Protein	Name
NM_001410799.1	NP_001397728.1	exportin-1 isoform 2
NM_003400.4	NP_003391.1	exportin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear export signal receptor activity	IDA IDA: Inferred from direct assay	29666234	GOA
enables nuclear export signal receptor activity	IMP IMP: Inferred from mutant phenotype	12724356	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10358091	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nucleocytoplasmic transport	IMP IMP: Inferred from mutant phenotype	11000203	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	22250199	GOA
acts upstream of or within protein export from nucleus	IMP IMP: Inferred from mutant phenotype	22427340	GOA
involved in protein export from nucleus	IMP IMP: Inferred from mutant phenotype	12773398	GOA
involved in protein export from nucleus	IPI IPI: Inferred from physical interaction	29666234	GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	29666234	GOA
involved in ribosomal large subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	12773398	GOA
involved in ribosomal small subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	12773398	GOA
involved in ribosomal subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	12724356	GOA
involved in ribosome biogenesis	IMP IMP: Inferred from mutant phenotype	12724356	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in annulate lamellae	IDA IDA: Inferred from direct assay	12210765	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23782956	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	17363900	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	23782956	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10557333	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPO1 Protein Structure

IBN_N

Xpo1

CRM1_C

0
200
400
600
800
1000
1071 a.a.

Protein Preferred Names

Protein Names

exportin-1

chromosome region maintenance 1 homolog

XPO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	XPO1	O14980	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	XPO1	O14980	DHX9	Homo sapiens	Q08211	Anti Bait CoIP	19955415
Intra	XPO1	O14980	PHB1	Homo sapiens	P35232	Anti Bait CoIP	16319068
Intra	XPO1	O14980	TP53	Homo sapiens	P04637	Anti Bait CoIP	17268548
Intra	XPO1	O14980	TP53	Homo sapiens	P04637	Anti Bait CoIP	18952844
Intra	XPO1	O14980	BIRC5	Homo sapiens	O15392	Pull Down	17099693
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	ITC	19339969
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	X-Ray Diffraction	19339969
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	Pull Down	19339969
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	SAXS	23850451
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	GMS	19339969
Intra	XPO1	O14980	SNUPN	Homo sapiens	O95149	Pull Down	19339972
Intra	XPO1	O14980	RCC1	Homo sapiens	P18754	Anti Tag CoIP	35271311
Cross	XPO1	O14980	rev	Human immunodeficiency virus	P04618	Pull Down	19339969
Cross	XPO1	O14980	rev	Human immunodeficiency virus	P04618	Pull Down	19339972

Cross: Cross-species interaction Intra: Intraspecies interaction

XPO1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81809	CRM1 Antibody (YA1554)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Primary Mediastinal Large B-Cell Lymphoma

Mediastinal Large B-Cell Lymphoma	Large Cell Lymphoma Of The Mediastinum
Med-Dlbcl	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type	Mediastinal Large B-Cell Lymphoma

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Mediastinal Gray Zone Lymphoma

Mediastinal B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma

Mediastinal Malignant Lymphoma

Lymphoma Of Mediastinum

Mediastinal Lymphoma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Chromosome 2p16.1-P15 Deletion Syndrome

2p15p16.1 Microdeletion Syndrome	2p15-P16.1 Microdeletion Syndrome
Del(2)(P15p16.1)	Monosomy 2p15p16.1
Monosomy 2p15-P16.1

Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Peroxisome Biogenesis Disorder 11a

PBD11A	Peroxisome Biogenesis Disorder Complementation Group 13
PBD-CG13	Cg13
Pbd-Cgh	Peroxisome Biogenesis Disorder Complementation Group H
Peroxisome Biogenesis Disorder, Type 11a	Peroxisome Biogenesis Disorder, Complementation Group 13

Retinitis Pigmentosa 61

RP61	Retinitis Pigmentosa, Type 61

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100423	Eltanexor	Inhibitor	99.84%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15970	Verdinexor	Inhibitor	99.91%	Unkown
HY-164710	Biotinylated leptomycin B		99.32%	Unkown
HY-144763	XPO1-IN-1	Inducer	/	Unkown
HY-161391	CW0134	Modulator	/	Unkown
HY-161392	CW2158	Modulator	/	Unkown
HY-RS15889	XPO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-163902	SP100030 analogue 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	XPO1	RGD	RGD:620517
Felis catus	XPO1	VGNC	VGNC:81260
Mus musculus	XPO1	MGD	MGI:2144013
Bos taurus	XPO1	VGNC	VGNC:36997
Macaca mulatta	XPO1	VGNC	VGNC:78812
Canis familiaris	XPO1	VGNC	VGNC:48460

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