2. Gene
  3. PIM2 - Pim-2 proto-oncogene, serine/threonine kinase Gene

PIM2 - Pim-2 proto-oncogene, serine/threonine kinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 11040 | Gene type: protein coding

About PIM2

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,913,182-48,919,024 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 45.7), appendix (RPKM 40.1) and 20 other tissues.

Summary

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent Apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

PIM2 Products(2)

mRNA Protein Name
NM_006875.4 NP_006866.2 serine/threonine-protein kinase pim-2
XM_047441792.1 XP_047297748.1 serine/threonine-protein kinase pim-2 isoform X1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18593906 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
20307683 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
18675992 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
20307683 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
18593906 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
20307683 GOA
involved in response to virus IEP
IEP: Inferred from expression pattern
16548883 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIM2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (32 - 286)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-2

pim-2 oncogene

pim-2h

proto-oncogene Pim-2 (serine threonine kinase)

PIM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PIM2 Q9P1W9 ZNF821 Homo sapiens O75541
Y2H Prey Pooling
25416956
Intra
PIM2 Q9P1W9 ATXN1 Homo sapiens P54253
Y2H Array
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-101870 Uzansertib Inhibitor / Phase 2
HY-15604 AZD1208 Inhibitor 99.71% Phase 1
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
HY-19322 PIM447 Inhibitor 99.52% Phase 1
HY-15604A AZD1208 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15698A CRT0066101 dihydrochloride Inhibitor 99.92% Unkown
HY-16576A SMI-4a Inhibitor 99.63% Unkown
HY-N4149 Quercetagetin Inhibitor 99.94% Unkown
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-101947 SMI-16a Inhibitor ≥98.0% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-15698 CRT0066101 Inhibitor 99.66% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-160006 PIM-IN-2 / Unkown
HY-123983 HS56 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-15698B CRT0066101 trihydrochloride Inhibitor / Unkown
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / Unkown
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / Unkown
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PIM2 MGD MGI:97587
Canis familiaris PIM2 VGNC VGNC:44565
Felis catus PIM2 VGNC VGNC:68861
Bos taurus PIM2 VGNC VGNC:32900
Rattus norvegicus PIM2 RGD RGD:1560759
Others PIM2 NCBI