CPSF6 - cleavage and polyadenylation specific factor 6 Gene

Homo sapiens

Also known as CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7

Gene ID: 11052 | Gene type: protein coding

About CPSF6

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,239,569-69,274,358 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.3), lymph node (RPKM 15.0) and 25 other tissues.

Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of Other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

CPSF6 Products(2)

mRNA	Protein	Name
NM_001300947.2	NP_001287876.1	cleavage and polyadenylation specificity factor subunit 6 isoform 2
NM_007007.3	NP_008938.2	cleavage and polyadenylation specificity factor subunit 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to RNA binding	IDA IDA: Inferred from direct assay	15169763	GOA
enables exon-exon junction complex binding	IDA IDA: Inferred from direct assay	19864460	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21295486	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14561889	GOA
enables ribosomal large subunit binding	IDA IDA: Inferred from direct assay	19864460	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway	IDA IDA: Inferred from direct assay	29276085	GOA
involved in mRNA 3'-end processing	IDA IDA: Inferred from direct assay	20695905	GOA
involved in mRNA alternative polyadenylation	IMP IMP: Inferred from mutant phenotype	20695905	GOA
involved in mRNA processing	IDA IDA: Inferred from direct assay	14690600	GOA
involved in positive regulation of RNA export from nucleus	IMP IMP: Inferred from mutant phenotype	19864460	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	23187700	GOA
involved in protein tetramerization	IDA IDA: Inferred from direct assay	20695905	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19864460	GOA
located in interchromatin granule	IDA IDA: Inferred from direct assay	17267687	GOA
part of mRNA cleavage and polyadenylation specificity factor complex	IDA IDA: Inferred from direct assay	23187700	GOA
part of mRNA cleavage factor complex	IDA IDA: Inferred from direct assay	9659921	GOA
part of mRNA cleavage factor complex	IPI IPI: Inferred from physical interaction	21295486	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	17267687	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	17267687	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19864460	GOA
located in paraspeckles	IDA IDA: Inferred from direct assay	9659921	GOA
located in perichromatin fibrils	IDA IDA: Inferred from direct assay	17267687	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	18809582	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPSF6 Protein Structure

0
100
200
300
400
500
551 a.a.

Protein Preferred Names

Protein Names

cleavage and polyadenylation specificity factor subunit 6

CPSF 68 kDa subunit

CPSF6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CPSF6	Q16630	TOLLIP	Homo sapiens	Q6FIE9	Y2H Prey Pooling	25416956
Intra	CPSF6	Q16630	PPIL1	Homo sapiens	Q9Y3C6	Y2H Array	25416956
Intra	CPSF6	Q16630	PPIL1	Homo sapiens	Q9Y3C6	Anti Tag CoIP	35271311
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Anti Tag CoIP	33961781
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Pull Down	22960638
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Anti Bait CoIP	22960638
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Pull Down	35177536
Intra	CPSF6	Q16630	NUDT21	Homo sapiens	O43809	Anti Tag CoIP	35271311
Intra	CPSF6	Q16630	PLSCR1	Homo sapiens	O15162	Pull Down	16189514
Intra	CPSF6	Q16630	WWP1	Homo sapiens	Q9H0M0	Anti Tag CoIP	33961781
Intra	CPSF6	Q16630	WWP1	Homo sapiens	Q9H0M0	Y2H Pooling	16189514
Intra	CPSF6	Q16630	WWP1	Homo sapiens	Q9H0M0	Y2H Pooling	19447967
Intra	CPSF6	Q16630	WWP1	Homo sapiens	Q9H0M0	Anti Tag CoIP	35271311
Intra	CPSF6	Q16630	ARMC7	Homo sapiens	Q9H6L4	Y2H Pooling	16189514
Intra	CPSF6	Q16630	WWP2	Homo sapiens	O00308	Anti Tag CoIP	35271311
Intra	CPSF6	Q16630	WWP2	Homo sapiens	O00308	Y2H Pooling	16189514
Intra	CPSF6	Q16630	OTUB2	Homo sapiens	Q96DC9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Carnitine-Acylcarnitine Translocase Deficiency

Cact Deficiency	Carnitine Acylcarnitine Translocase Deficiency
CACTD	Carnitine-Acylcarnitine Carrier Deficiency

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120072	PF-3450074	Inhibitor	98.44%	Unkown
HY-RS03120	CPSF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CPSF6	VGNC	VGNC:61144
Mus musculus	CPSF6	MGD	MGI:1913948
Macaca mulatta	CPSF6	VGNC	VGNC:71401
Bos taurus	CPSF6	VGNC	VGNC:27674
Canis familiaris	CPSF6	VGNC	VGNC:39577
Rattus norvegicus	CPSF6	RGD	RGD:1304640

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