RPP14 - ribonuclease P/MRP subunit p14 Gene

Homo sapiens

Also known as P14

Gene ID: 11102 | Gene type: protein coding

About RPP14

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:58,306,245-58,320,193 (from NCBI)

This gene has 6 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in thyroid (RPKM 4.8), kidney (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]

RPP14 Products(2)

mRNA	Protein	Name
NM_001098783.3	NP_001092253.1	ribonuclease P protein subunit p14
NM_007042.6	NP_008973.1	ribonuclease P protein subunit p14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15096576	GOA
enables ribonuclease P RNA binding	IDA IDA: Inferred from direct assay	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: Inferred from direct assay	30454648	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in tRNA 5'-leader removal	IDA IDA: Inferred from direct assay	16723659	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of multimeric ribonuclease P complex	IDA IDA: Inferred from direct assay	16723659	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	10444065	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPP14 Protein Structure

RNase_P_Rpp14

0
100
124 a.a.

Protein Preferred Names

Protein Names

ribonuclease P protein subunit p14

ribonuclease P/MRP 14kDa subunit

Related Diseases

Diseases

Alias

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Chromosome 16p11.2 Deletion Syndrome

Distal 16p11.2 Microdeletion Syndrome	16p11.2 Deletion Syndrome
Del(16)(P11.2)	Microdeletion 16p11.2
Monosomy 16p11.2	Autism, Susceptibility To, 14a
Auts14a	Distal Del(16)(P11.2)
Distal Monosomy 16p11.2

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12212	RPP14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPP14	RGD	RGD:1305436
Canis familiaris	RPP14	VGNC	VGNC:108255
Mus musculus	RPP14	MGD	MGI:1914303
Bos taurus	RPP14	VGNC	VGNC:109387

Name
Email *

	Sorry, but the email address you supplied was invalid.