RPP30 - ribonuclease P/MRP subunit p30 Gene

Homo sapiens

Also known as TSG15

Gene ID: 10556 | Gene type: protein coding

About RPP30

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:90,871,974-90,908,556 (from NCBI)

This gene has 10 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in testis (RPKM 4.1), lymph node (RPKM 2.7) and 25 other tissues.

Summary

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

RPP30 Products(2)

mRNA	Protein	Name
NM_001104546.2	NP_001098016.1	ribonuclease P protein subunit p30 isoform a
NM_006413.5	NP_006404.1	ribonuclease P protein subunit p30 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15096576	GOA
enables ribonuclease P RNA binding	IDA IDA: Inferred from direct assay	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: Inferred from direct assay	30454648	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in tRNA 5'-leader removal	IDA IDA: Inferred from direct assay	16723659	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of multimeric ribonuclease P complex	IDA IDA: Inferred from direct assay	16723659	GOA
part of ribonuclease MRP complex	IDA IDA: Inferred from direct assay	16723659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPP30 Protein Structure

RNase_P_p30

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

ribonuclease P protein subunit p30

RNase P subunit 2

RPP30 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPP30	P78346	POP5	Homo sapiens	Q969H6	Y2H Array	32296183
Intra	RPP30	P78346	POP5	Homo sapiens	Q969H6	Validated Y2H	32296183
Intra	RPP30	P78346	POP5	Homo sapiens	Q969H6	Anti Tag CoIP	28514442
Intra	RPP30	P78346	POP5	Homo sapiens	Q969H6	Y2H Prey Pooling	32296183
Intra	RPP30	P78346	RPP14	Homo sapiens	O95059	Anti Tag CoIP	28514442
Intra	RPP30	P78346	RPP14	Homo sapiens	O95059	Anti Tag CoIP	35271311
Intra	RPP30	P78346	RPP14	Homo sapiens	O95059	Pull Down	15096576
Intra	RPP30	P78346	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	RPP30	P78346	HMG20A	Homo sapiens	Q9NP66	Y2H Array	25416956
Intra	RPP30	P78346	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	RPP30	P78346	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12215	RPP30 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPP30	VGNC	VGNC:34123
Canis familiaris	RPP30	VGNC	VGNC:45723
Rattus norvegicus	RPP30	RGD	RGD:1595116
Felis catus	RPP30	VGNC	VGNC:64745
Mus musculus	RPP30	MGD	MGI:1859683
Macaca mulatta	RPP30	VGNC	VGNC:77040

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