POP5 - POP5 homolog, ribonuclease P/MRP subunit Gene

Homo sapiens

Also known as RPP2; RPP20; hPop5; HSPC004

Gene ID: 51367 | Gene type: protein coding

About POP5

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,578,764-120,581,402 (from NCBI)

This gene has 9 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in adrenal (RPKM 15.3), fat (RPKM 13.2) and 25 other tissues.

Summary

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

POP5 Products(2)

mRNA	Protein	Name
NM_015918.4	NP_057002.2	ribonuclease P/MRP protein subunit POP5 isoform a
NM_198202.2	NP_937845.1	ribonuclease P/MRP protein subunit POP5 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15096576	GOA
enables ribonuclease P RNA binding	IDA IDA: Inferred from direct assay	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: Inferred from direct assay	30454648	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in tRNA 5'-leader removal	IDA IDA: Inferred from direct assay	16723659	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of multimeric ribonuclease P complex	IDA IDA: Inferred from direct assay	16723659	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	11413139	GOA
part of ribonuclease MRP complex	IDA IDA: Inferred from direct assay	16723659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POP5 Protein Structure

RNase_P_Rpp14

0
100
163 a.a.

Protein Preferred Names

Protein Names

ribonuclease P/MRP protein subunit POP5

processing of precursor 5, ribonuclease P/MRP subunit

Related Diseases

Diseases

Alias

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Anauxetic Dysplasia 2

ANXD2

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Enterocele

Vaginal Enterocele	Hernia
Hernias

Prolapse Of Female Genital Organ

Cholestasis, Intrahepatic, Of Pregnancy, 1

ICP1	Intrahepatic Cholestasis Of Pregnancy 1
Cholestasis, Pregnancy-Related, 1	Pregnancy Related Cholestasis 1
Cholestasis Of Pregnancy, Intrahepatic 1	Obstetric Cholestasis
Pregnancy-Related Cholestasis	Recurrent Intrahepatic Cholestasis Of Pregnancy
Cholestasis, Intrahepatic, Of Pregnancy, Type 1	Cholestasis Of Pregnancy

Anismus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10877	POP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	POP5	MGD	MGI:2151221
Felis catus	POP5	VGNC	VGNC:107718
Bos taurus	POP5	VGNC	VGNC:33165
Canis familiaris	POP5	VGNC	VGNC:44817
Rattus norvegicus	POP5	RGD	RGD:1311819

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