PSIP1 - PC4 and SRSF1 interacting protein 1 Gene

Homo sapiens

Also known as p52; p75; PAIP; DFS70; LEDGF; PSIP2

Gene ID: 11168 | Gene type: protein coding

About PSIP1

Cytogenetic location: 9p22.3 Genomic coordinates (GRCh38): 9:15,464,066-15,510,970 (from NCBI)

This gene has 11 transcripts (splice variants), 255 orthologues, 4 paralogues and is associated with 66 phenotypes. Ubiquitous expression in brain (RPKM 41.2), ovary (RPKM 33.4) and 24 other tissues.

Summary

Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription coactivator activity. Involved in mRNA 5'-splice site recognition and positive regulation of transcription by RNA polymerase II. Located in heterochromatin; nuclear periphery; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PSIP1 Products(5)

mRNA	Protein	Name
NM_001128217.3	NP_001121689.1	PC4 and SFRS1-interacting protein isoform 2
NM_001317898.3	NP_001304827.1	PC4 and SFRS1-interacting protein isoform 3
NM_001317900.3	NP_001304829.1	PC4 and SFRS1-interacting protein isoform 4
NM_021144.4	NP_066967.3	PC4 and SFRS1-interacting protein isoform 1
NM_033222.5	NP_150091.2	PC4 and SFRS1-interacting protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	9822615	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20974633	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9885563	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9822615	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA 5'-splice site recognition	IDA IDA: Inferred from direct assay	9885563	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9822615	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in heterochromatin	IDA IDA: Inferred from direct assay	12796494	GOA
located in nuclear periphery	IDA IDA: Inferred from direct assay	11512661	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	11512661	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	9885563	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12796494	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSIP1 Protein Structure

PWWP

LEDGF

0
100
200
300
400
500
530 a.a.

Protein Preferred Names

Protein Names

PC4 and SFRS1-interacting protein

CLL-associated antigen KW-7

Recombinant PSIP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79208	LEDGF p52 Protein, Human	O75475-2/NP_066967 (M1-Q333)	≥95%

Related Diseases

Diseases

Alias

Olfactory Neuroblastoma

Esthesioneuroblastoma	Asthesioneuroblastoma
Esthesioneuroepithelioma	Olfactory Esthesioneuroblastoma
Paranasal Sinus Olfactory Neuroblastoma	Esthesioneuroblastoma, Olfactory
Esthesioneuroblastoma Of Nasal Cavity

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Granulomatous Disease, Chronic, X-Linked

CGDX	Chronic Granulomatous Disease, X-Linked
X-Linked Chronic Granulomatous Disease	Cgd
Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked	Cdgx
X-Linked Chronic Cytochrome B-Negative Granulomatous Disease	Chronic Granulomatous Disease Cytochrome B-Negative X-Linked
Chronic Granulomatous Disease Cytochrome B-Positive X-Linked	Granulomatous Disease, Chronic, X-Linked, Variant

Retinal Degeneration

Degeneration Of Retina

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W023758	HDGFRP2/PSIP1-IN-1	Inhibitor	/	Unkown
HY-RS11289	PSIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PSIP1	VGNC	VGNC:76437
Mus musculus	PSIP1	MGD	MGI:2142116
Rattus norvegicus	PSIP1	RGD	RGD:631439
Canis familiaris	PSIP1	VGNC	VGNC:45087
Felis catus	PSIP1	VGNC	VGNC:69103
Bos taurus	PSIP1	VGNC	VGNC:33436

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