RPAP2 - RNA polymerase II associated protein 2 Gene

Homo sapiens

Also known as Rtr1; C1orf82

Gene ID: 79871 | Gene type: protein coding

About RPAP2

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:92,299,059-92,402,056 (from NCBI)

This gene has 3 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 2.5), endometrium (RPKM 2.0) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and snRNA transcription. Located in cytosol and nucleolus. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]

RPAP2 Products(1)

mRNA	Protein	Name
NM_024813.3	NP_079089.2	putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IMP IMP: Inferred from mutant phenotype	22137580	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24656813	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	30118681	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in PERK-mediated unfolded protein response	IDA IDA: Inferred from direct assay	30118681	GOA
involved in snRNA transcription	IMP IMP: Inferred from mutant phenotype	22137580	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22137580	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22137580	GOA
part of transcription preinitiation complex	IDA IDA: Inferred from direct assay	22231121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPAP2 Protein Structure

RPAP2_Rtr1

0
100
200
300
400
500
612 a.a.

Protein Preferred Names

Protein Names

putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

RPAP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPAP2	Q8IXW5	RPRD1A	Homo sapiens	Q96P16-1	Pull Down	24997600
Intra	RPAP2	Q8IXW5	PIH1D1	Homo sapiens	Q9NWS0	Y2H Array	32296183
Intra	RPAP2	Q8IXW5	PIH1D1	Homo sapiens	Q9NWS0	Y2H Prey Pooling	32296183
Intra	RPAP2	Q8IXW5	PIH1D1	Homo sapiens	Q9NWS0	Anti Tag CoIP	35271311
Intra	RPAP2	Q8IXW5	PIH1D1	Homo sapiens	Q9NWS0	Validated Y2H	32296183
Intra	RPAP2	Q8IXW5	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	RPAP2	Q8IXW5	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	RPAP2	Q8IXW5	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	RPAP2	Q8IXW5	GPN1	Homo sapiens	Q9HCN4	Anti Tag CoIP	35271311
Intra	RPAP2	Q8IXW5	GPN1	Homo sapiens	Q9HCN4	Y2H Prey Pooling	32296183
Intra	RPAP2	Q8IXW5	GPN1	Homo sapiens	Q9HCN4	TAP	24981860
Intra	RPAP2	Q8IXW5	GPN1	Homo sapiens	Q9HCN4	Y2H Array	32296183
Intra	RPAP2	Q8IXW5	GPN1	Homo sapiens	Q9HCN4	Validated Y2H	32296183
Intra	RPAP2	Q8IXW5	RPRD1B	Homo sapiens	Q9NQG5	Pull Down	24997600
Intra	RPAP2	Q8IXW5	RPRD1B	Homo sapiens	Q9NQG5	ITC	24997600

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cholestasis, Intrahepatic, Of Pregnancy, 1

ICP1	Intrahepatic Cholestasis Of Pregnancy 1
Cholestasis, Pregnancy-Related, 1	Pregnancy Related Cholestasis 1
Cholestasis Of Pregnancy, Intrahepatic 1	Obstetric Cholestasis
Pregnancy-Related Cholestasis	Recurrent Intrahepatic Cholestasis Of Pregnancy
Cholestasis, Intrahepatic, Of Pregnancy, Type 1	Cholestasis Of Pregnancy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12148	RPAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPAP2	VGNC	VGNC:64729
Rattus norvegicus	RPAP2	RGD	RGD:1309034
Mus musculus	RPAP2	MGD	MGI:2141142
Bos taurus	RPAP2	VGNC	VGNC:34099
Macaca mulatta	RPAP2	VGNC	VGNC:76828

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