2. Gene
  3. Abl1 - c-abl oncogene 1, non-receptor tyrosine kinase Gene

Abl1 - c-abl oncogene 1, non-receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Abl; c-Abl; E430008G22Rik

Gene ID: 11350 | Gene type: protein coding

About Abl1

Chromosome 2: 31,578,388-31,694,239 forward strand.GRCm39:CM000995.3

This gene has 10 transcripts (splice variants), 204 orthologues, 32 paralogues and is associated with 66 phenotypes. Ubiquitous expression in ovary adult (RPKM 24.4), limb E14.5 (RPKM 24.2) and 28 other tissues.

Summary

Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of blood vessel branching; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Abl1 Products(5)

mRNA Protein Name
NM_001283045.1 NP_001269974.1 tyrosine-protein kinase ABL1 isoform c
NM_001283046.1 NP_001269975.1 tyrosine-protein kinase ABL1 isoform d
NM_001283047.1 NP_001269976.1 tyrosine-protein kinase ABL1 isoform e
NM_001112703.2 NP_001106174.1 tyrosine-protein kinase ABL1 isoform a
NM_009594.4 NP_033724.2 tyrosine-protein kinase ABL1 isoform b

Abl1 Protein Structure

SH3_Abl

SH3_Abl: cd11850 (64 - 117)

SH2_ABL

SH2_ABL: cd09935 (122 - 215)

PTKc_Abl

PTKc_Abl: cd05052 (234 - 496)

FABD

FABD: smart00808 (998 - 1122)

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  • 1123 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase ABL1

Abelson murine leukemia oncogene

Abelson tyrosine-protein kinase 1

abelson murine leukemia viral oncogene homolog 1

c-abl oncogene 1, receptor tyrosine kinase

c-abl protein, type I

c-abl protein, type II

c-abl protein, type III

p150

proto-oncogene c-Abl

proto-oncogene tyrosine-protein kinase ABL1

v-abl Abelson murine leukemia oncogene 1

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104010 Asciminib Inhibitor 99.88% Yes
HY-15728 Radotinib 98.92% Yes
HY-104010A Asciminib hydrochloride Inhibitor 99.84% Yes
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-13024 Rebastinib 99.91% Phase 2
HY-137460 Vodobatinib Inhibitor 99.85% Phase 2
HY-148794 Risvodetinib Inhibitor 99.21% Phase 2
HY-13072 Cenisertib Inhibitor 99.86% Phase 1
Pre-clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125845 (S,R,S)-AHPC 99.13% Unkown
HY-125834 GMB-475 98.98% Unkown
HY-148063 DB0614 98.80% Unkown
HY-103032 Multi-kinase inhibitor 1 Inhibitor 99.34% Unkown
HY-148061 DB1113 99.28% Unkown
HY-W143698 PDGFRα kinase inhibitor 2 Inhibitor ≥98.0% Unkown
HY-12338 ON 146040 Inhibitor 95.05% Unkown
HY-110402 (S,R,S)-AHPC TFA / Unkown
HY-107447S N-Deshydroxyethyl Dasatinib-d8 / Unkown
HY-101268 CHMFL-ABL-053 Inhibitor / Unkown
HY-101763B (S,R,S)-AHPC dihydrochloride / Unkown
HY-119177 PD173956 Inhibitor / Unkown
HY-130297 PROTAC BCR-ABL1 ligand 1 Inhibitor / Unkown
HY-145887 BCR-ABL1-IN-1 99.82% Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-155112 Antiproliferative agent-30 Inhibitor / Unkown
HY-161445 (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH / Unkown
HY-162489 Tyrosine kinase-IN-8 Inhibitor / Unkown
HY-162952 cSRC/BCR-ABL1-IN-1 / Unkown
HY-18819 BCR-ABL-IN-2 Inhibitor / Unkown
HY-RS00102 ABL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00103 Abl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00104 ABL1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-13072B Cenisertib benzoate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abl1 NCBI NCBI:25