Ada - adenosine deaminase Gene

Mus musculus

Gene ID: 11486 | Gene type: protein coding

About Ada

Chromosome 2: 163,568,504-163,592,159 reverse strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 40 phenotypes. Biased expression in small intestine adult (RPKM 276.4), placenta adult (RPKM 134.5) and 4 other tissues.

Summary

Enables 2'-deoxyadenosine deaminase activity; Adenosine Deaminase activity; and zinc ion binding activity. Involved in allantoin metabolic process and purine nucleoside monophosphate metabolic process. Acts upstream of or within several processes, including animal organ development; nucleobase-containing small molecule metabolic process; and positive regulation of lymphocyte activation. Located in cytoplasm. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and sensory organ. Used to study Adenosine Deaminase deficiency. Human ortholog(s) of this gene implicated in Adenosine Deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (Adenosine Deaminase). [provided by Alliance of Genome Resources, Apr 2022]

Ada Products(2)

mRNA	Protein	Name
NM_007398.4	NP_031424.1	adenosine deaminase
NM_001272052.1	NP_001258981.1	adenosine deaminase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2'-deoxyadenosine deaminase activity	IMP IMP: Inferred from mutant phenotype	10720488	MGI
enables adenosine deaminase activity	IDA IDA: Inferred from direct assay	718989	MGI
enables adenosine deaminase activity	IMP IMP: Inferred from mutant phenotype	7731963	MGI
enables zinc ion binding	IDA IDA: Inferred from direct assay	8672487	MGI
enables zinc ion binding	IMP IMP: Inferred from mutant phenotype	8634299	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in AMP catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in AMP salvage	IDA IDA: Inferred from direct assay	8064675	MGI
acts upstream of B cell proliferation	IMP IMP: Inferred from mutant phenotype	14607964	MGI
involved in GMP salvage	IDA IDA: Inferred from direct assay	718989	MGI
acts upstream of or within Peyer's patch development	IMP IMP: Inferred from mutant phenotype	10720488	MGI
acts upstream of T cell activation	IMP IMP: Inferred from mutant phenotype	10845921	MGI
acts upstream of T cell differentiation	IMP IMP: Inferred from mutant phenotype	7731963	MGI
acts upstream of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	11067867	MGI
acts upstream of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11435465	MGI
acts upstream of or within adenosine catabolic process	IDA IDA: Inferred from direct assay	1618849	MGI
involved in adenosine catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
acts upstream of or within adenosine catabolic process	IMP IMP: Inferred from mutant phenotype	7670465	MGI
involved in allantoin metabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in allantoin metabolic process	IMP IMP: Inferred from mutant phenotype	10720488	MGI
acts upstream of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	11067867	MGI
involved in amide catabolic process	IDA IDA: Inferred from direct assay	8064675	MGI
involved in amide catabolic process	IMP IMP: Inferred from mutant phenotype	10720488	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	7670465	MGI
acts upstream of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	11435465	MGI
involved in dAMP catabolic process	IMP IMP: Inferred from mutant phenotype	10720488	MGI
acts upstream of or within dATP catabolic process	IDA IDA: Inferred from direct assay	7592575	MGI
acts upstream of or within dATP catabolic process	IMP IMP: Inferred from mutant phenotype	7670465	MGI
acts upstream of or within deoxyadenosine catabolic process	IDA IDA: Inferred from direct assay	7592575	MGI
acts upstream of or within deoxyadenosine catabolic process	IMP IMP: Inferred from mutant phenotype	7670465	MGI
involved in deoxyadenosine catabolic process	IMP IMP: Inferred from mutant phenotype	10720488	MGI
acts upstream of or within embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	7670465	MGI
acts upstream of or within germinal center B cell differentiation	IMP IMP: Inferred from mutant phenotype	14607964	MGI
acts upstream of germinal center formation	IMP IMP: Inferred from mutant phenotype	14607964	MGI
acts upstream of or within hypoxanthine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10720488	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	7731963	MGI
acts upstream of or within inosine biosynthetic process	IDA IDA: Inferred from direct assay	1618849	MGI
involved in inosine biosynthetic process	IDA IDA: Inferred from direct assay	8672487	MGI
acts upstream of or within inosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	7731963	MGI
acts upstream of leukocyte migration	IGI IGI: Inferred from genetic interaction	15240734	MGI
acts upstream of leukocyte migration	IMP IMP: Inferred from mutant phenotype	15240734	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	7670465	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	10899903	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	7670465	MGI
acts upstream of mature B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	14607964	MGI
acts upstream of mucus secretion	IGI IGI: Inferred from genetic interaction	15240734	MGI
acts upstream of mucus secretion	IMP IMP: Inferred from mutant phenotype	15240734	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	7670465	MGI
acts upstream of or within negative regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	15240734	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	10899903	MGI
acts upstream of or within negative regulation of leukocyte migration	IGI IGI: Inferred from genetic interaction	15240734	MGI
acts upstream of or within negative regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	15240734	MGI
acts upstream of or within negative regulation of mature B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	14607964	MGI
acts upstream of or within negative regulation of mucus secretion	IGI IGI: Inferred from genetic interaction	15240734	MGI
acts upstream of or within negative regulation of mucus secretion	IMP IMP: Inferred from mutant phenotype	15240734	MGI
acts upstream of or within negative regulation of penile erection	IMP IMP: Inferred from mutant phenotype	18340377	MGI
acts upstream of or within negative regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	11067867	MGI
acts upstream of penile erection	IMP IMP: Inferred from mutant phenotype	18340377	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	9272950	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	14607964	MGI
acts upstream of or within positive regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	10845921	MGI
acts upstream of or within positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	7731963	MGI
acts upstream of or within positive regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	11067867	MGI
acts upstream of or within positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11435465	MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	11067867	MGI
acts upstream of or within positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	11435465	MGI
acts upstream of or within positive regulation of germinal center formation	IMP IMP: Inferred from mutant phenotype	14607964	MGI
acts upstream of or within positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	16626672	MGI
acts upstream of or within positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	18340377	MGI
acts upstream of or within regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	7670465	MGI
acts upstream of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	18340377	MGI
acts upstream of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	11067867	MGI
acts upstream of or within trophectodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	9272950	MGI
acts upstream of or within xanthine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10720488	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	7691243	MGI
is active in cytosol	IDA IDA: Inferred from direct assay	16742956	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ada Protein Structure

A_deaminase

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

adenosine deaminase

adenosine aminohydrolase

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17377	Vicriviroc maleate		99.91%	Phase 3
HY-105017	Evodenoson	Agonist	99.74%	Phase 2

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103160A	EHNA hydrochloride	Inhibitor	99.61%	Unkown
HY-W011552	2'-O-Methyladenosine		99.44%	Unkown
HY-N7368	Hibifolin	Inhibitor	99.70%	Unkown
HY-158009	SGF29-IN-1	Inhibitor	≥98.0%	Unkown
HY-103237	L-Adenosine	Inhibitor	≥97.0%	Unkown
HY-116578	Metopimazine		98.03%	Unkown
HY-103159	1-Deazaadenosine	Inhibitor	≥98.0%	Unkown
HY-114175A	Adenosine deaminase, Calf Spleen		/	Unkown
HY-D0855A	ADA disodium		≥98.0%	Unkown
HY-D0855	ADA		≥97.0%	Unkown
HY-W753672	2'-O-Methyladenosine-d3		97.54%	Unkown
HY-117260	Coformycin	Inhibitor	/	Unkown
HY-103160B	EHNA	Inhibitor	/	Unkown
HY-P5201S	VTSEGAGLQLQK-13C6,15N2		/	Unkown
HY-RS00258	ADA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00259	Ada Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00260	Ada Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00261	ADA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W129499	ADA sodium		/	Unkown
HY-137294	BTPTT-4F		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ada	NCBI	NCBI:100
Macaca fascicularis	Ada	NCBI	NCBI:102137458
Rattus norvegicus	Ada	NCBI	NCBI:24165
Macaca mulatta	Ada	NCBI	NCBI:717897

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