Ada - adenosine deaminase Gene

Rattus norvegicus

Gene ID: 24165 | Gene type: protein coding

About Ada

Primary_assembly 3: 152,398,747-152,447,088 reverse strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 51 phenotypes. Biased expression in Lung (RPKM 737.7), Thymus (RPKM 689.8) and 7 other tissues.

Summary

Enables Adenosine Deaminase activity and purine nucleoside binding activity. Involved in several processes, including adenosine metabolic process; negative regulation of circadian sleep/wake cycle, non-REM sleep; and response to vitamin E. Located in dendrite cytoplasm; extracellular space; and neuronal cell body. Used to study hypertension; peritonitis; and pulmonary edema. Biomarker of hyperglycemia; leptospirosis; lung disease; and trypanosomiasis. Human ortholog(s) of this gene implicated in Adenosine Deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (Adenosine Deaminase). [provided by Alliance of Genome Resources, Apr 2022]

Ada Products(1)

mRNA	Protein	Name
NM_130399.2	NP_569083.1	adenosine deaminase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenosine deaminase activity	IDA IDA: Inferred from direct assay	3746429	RGD
enables purine nucleoside binding	IDA IDA: Inferred from direct assay	3746429	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenosine catabolic process	IMP IMP: Inferred from mutant phenotype	30269308	RGD
involved in adenosine metabolic process	IDA IDA: Inferred from direct assay	3746429	RGD
involved in histamine secretion	IMP IMP: Inferred from mutant phenotype	19066225	RGD
involved in negative regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	19066225	RGD
involved in regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	3876160	RGD
involved in regulation of circadian sleep/wake cycle, sleep	IEP IEP: Inferred from expression pattern	11038259	RGD
involved in response to L-arginine	IEP IEP: Inferred from expression pattern	22623885	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	27491636	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	15966013	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	20735412	RGD
involved in response to vitamin E	IDA IDA: Inferred from direct assay	16716042	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16716042	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	2253038	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16563876	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	2253038	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ada Protein Structure

A_deaminase

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

adenosine deaminase

adenosine aminohydrolase

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17377	Vicriviroc maleate		99.91%	Phase 3
HY-105017	Evodenoson	Agonist	99.74%	Phase 2

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103160A	EHNA hydrochloride	Inhibitor	99.61%	Unkown
HY-W011552	2'-O-Methyladenosine		99.44%	Unkown
HY-N7368	Hibifolin	Inhibitor	99.70%	Unkown
HY-158009	SGF29-IN-1	Inhibitor	≥98.0%	Unkown
HY-116578	Metopimazine		98.03%	Unkown
HY-103237	L-Adenosine	Inhibitor	≥97.0%	Unkown
HY-103159	1-Deazaadenosine	Inhibitor	≥98.0%	Unkown
HY-114175A	Adenosine deaminase, Calf Spleen		/	Unkown
HY-D0855A	ADA disodium		≥98.0%	Unkown
HY-D0855	ADA		≥97.0%	Unkown
HY-W753672	2'-O-Methyladenosine-d3		97.54%	Unkown
HY-117260	Coformycin	Inhibitor	/	Unkown
HY-P5201S	VTSEGAGLQLQK-13C6,15N2		/	Unkown
HY-RS00258	ADA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00259	Ada Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00260	Ada Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00261	ADA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W129499	ADA sodium		/	Unkown
HY-137294	BTPTT-4F		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ada	NCBI	NCBI:100
Macaca fascicularis	Ada	NCBI	NCBI:102137458
Mus musculus	Ada	NCBI	NCBI:11486
Macaca mulatta	Ada	NCBI	NCBI:717897

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