GBP5 - guanylate binding protein 5 Gene

Homo sapiens

Also known as GBP-5

Gene ID: 115362 | Gene type: protein coding

About GBP5

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,256,189-89,272,860 (from NCBI)

This gene has 5 transcripts (splice variants), 98 orthologues and 10 paralogues. Biased expression in appendix (RPKM 33.2), lymph node (RPKM 19.8) and 11 other tissues.

Summary

This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

GBP5 Products(3)

mRNA	Protein	Name
NM_001134486.4	NP_001127958.1	guanylate-binding protein 5 isoform 1
NM_001391920.1	NP_001378849.1	guanylate-binding protein 5 isoform 2
NM_052942.5	NP_443174.1	guanylate-binding protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	26996307	GOA
enables endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	31091448	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables molecular function inhibitor activity	IDA IDA: Inferred from direct assay	31091448	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21151871	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21151871	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	17266443	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	26996307	GOA
involved in positive regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	22461501	GOA
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	22461501	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	22461501	GOA
involved in protein localization to Golgi apparatus	IDA IDA: Inferred from direct assay	21151871	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	26996307	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17266443	GOA
is active in Golgi membrane	IDA IDA: Inferred from direct assay	31091448	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17266443	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21151871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GBP5 Protein Structure

GBP

GBP_C

0
100
200
300
400
500
586 a.a.

Protein Preferred Names

Protein Names

guanylate-binding protein 5

GBP-TA antigen

GBP5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GBP5	Q96PP8	GBP4	Homo sapiens	Q96PP9	Anti Tag CoIP	21151871
Intra	GBP5	Q96PP8	GBP4	Homo sapiens	Q96PP9	BiFC	21151871
Intra	GBP5	Q96PP8	GBP3	Homo sapiens	Q9H0R5	BiFC	21151871
Intra	GBP5	Q96PP8	GBP3	Homo sapiens	Q9H0R5	Anti Tag CoIP	21151871
Intra	GBP5	Q96PP8	GBP1	Homo sapiens	P32455	BiFC	21151871
Intra	GBP5	Q96PP8	GBP1	Homo sapiens	P32455	Anti Tag CoIP	21151871
Intra	GBP5	Q96PP8	GBP1	Homo sapiens	P32455	Anti Tag CoIP	33961781
Intra	GBP5	Q96PP8	GBP1	Homo sapiens	P32455	Anti Tag CoIP	28514442
Intra	GBP5	Q96PP8	GBP2	Homo sapiens	P32456	BiFC	21151871
Intra	GBP5	Q96PP8	GBP2	Homo sapiens	P32456	Anti Tag CoIP	21151871
Intra	GBP5	Q96PP8	GBP5	Homo sapiens	Q96PP8	GMS	20180847
Intra	GBP5	Q96PP8	GBP5	Homo sapiens	Q96PP8	BiFC	21151871
Intra	GBP5	Q96PP8	ACSM1	Homo sapiens	Q08AH1	Anti Tag CoIP	33961781
Intra	GBP5	Q96PP8	APOL2	Homo sapiens	Q9BQE5	Anti Tag CoIP	33961781
Intra	GBP5	Q96PP8	GBP5	Homo sapiens	Q96PP8	Y2H Pooling	16189514
Intra	GBP5	Q96PP8	ACSM1	Homo sapiens	Q08AH1	Anti Tag CoIP	28514442
Intra	GBP5	Q96PP8	APOL2	Homo sapiens	Q9BQE5	Anti Tag CoIP	28514442
Intra	GBP5	Q96PP8	GBP5	Homo sapiens	Q96PP8	Anti Tag CoIP	21151871
Intra	GBP5	Q96PP8	GBP5	Homo sapiens	Q96PP8	Y2H	21151871

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05311	GBP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GBP5	RGD	RGD:1311040
Mus musculus	GBP5	MGD	MGI:2429943
Bos taurus	GBP5	VGNC	VGNC:59183

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