Parp2 - poly (ADP-ribose) polymerase family, member 2 Gene

Mus musculus

Also known as ARTD2; Adprt2; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2

Gene ID: 11546 | Gene type: protein coding

About Parp2

Chromosome 14: 51,045,298-51,058,758 forward strand.GRCm39:CM001007.3

This gene has 8 transcripts (splice variants), 185 orthologues, 2 paralogues and is associated with 6 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 2.7), liver E14 (RPKM 15.1) and 25 other tissues.

Summary

Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Apr 2022]

Parp2 Products(1)

mRNA	Protein	Name
NM_009632.3	NP_033762.1	poly [ADP-ribose] polymerase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	10364231	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11948190	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within base-excision repair	IMP IMP: Inferred from mutant phenotype	11948190	MGI
involved in decidualization	IMP IMP: Inferred from mutant phenotype	34580230	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	12065591	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	15615785	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	15615785	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12065591	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Parp2 Protein Structure

PLN03124

0
100
200
300
400
500
559 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase 2

ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2	ADP-ribosyltransferase (NAD+
poly (ADP-ribose) polymerase) 2	ADP-ribosyltransferase diphtheria toxin-like 2
DNA ADP-ribosyltransferase PARP2	NAD(+) ADP-ribosyltransferase 2
poly[ADP-ribose] synthase 2	poly[ADP-ribose] synthetase 2
protein poly-ADP-ribosyltransferase PARP2

Related Agents

Approval

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10162	Olaparib	Inhibitor	99.98%	Yes
HY-16106	Talazoparib	Inhibitor	99.89%	Unkown
HY-10619	Niraparib	Inhibitor	99.96%	Yes
HY-10617A	Rucaparib	Inhibitor	99.97%	Unkown
HY-10619B	Niraparib tosylate	Inhibitor	99.99%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-10619A	Niraparib hydrochloride	Inhibitor	99.41%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.82%	Yes
HY-10619E	Niraparib tosylate hydrate	Inhibitor	99.97%	Yes
HY-10617C	Rucaparib tartrate	Inhibitor	/	Unkown
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	Unkown
HY-10617D	Rucaparib acetate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-122661	Mefuparib hydrochloride	Inhibitor	98.62%	Phase 4
HY-132167	Saruparib	Inhibitor	99.76%	Phase 3
HY-10129	Veliparib	Inhibitor	99.78%	Phase 3
HY-10130	Veliparib dihydrochloride	Inhibitor	99.98%	Phase 3
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2
HY-137457A	Venadaparib hydrochloride	Inhibitor	/	Phase 2
HY-105303	CEP-9722	Inhibitor	/	Phase 2
HY-13536	AZD-2461	Inhibitor	99.88%	Phase 1
HY-115552	Simmiparib	Inhibitor	99.51%	Phase 1

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-13688A	PJ34	Inhibitor	98.11%	Unkown
HY-13990	NVP-TNKS656	Inhibitor	99.66%	Unkown
HY-13688	PJ34 hydrochloride	Inhibitor	99.91%	Unkown
HY-150207	RBN-3143	Inhibitor	99.24%	Unkown
HY-14478	UPF 1069	Inhibitor	99.10%	Unkown
HY-148566	OUL232	Inhibitor	99.86%	Unkown
HY-100225	ME0328	Inhibitor	99.64%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-137457	Venadaparib	Inhibitor	98.11%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-18954	NMS-P118	Inhibitor	99.54%	Unkown
HY-156419	PARP7-IN-16	Inhibitor	99.91%	Unkown
HY-145584	Nesuparib	Inhibitor	99.43%	Unkown
HY-132297A	PARP1-IN-5 dihydrochloride	Inhibitor	97.56%	Unkown
HY-108632	BYK204165	Inhibitor	98.66%	Unkown
HY-10614	A-966492	Inhibitor	99.95%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.89%	Unkown
HY-149800	PARP-1-IN-3	Inhibitor	99.30%	Unkown
HY-156419A	PARP7-IN-16 free base	Inhibitor	99.40%	Unkown
HY-121719	TIQ-A	Inhibitor	99.85%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-105692	DR2313	Inhibitor	99.66%	Unkown
HY-155993	YCH1899	Inhibitor	99.39%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-133124	PARP/PI3K-IN-1	Inhibitor	99.43%	Unkown
HY-102035	PARP-2-IN-1	Inhibitor	99.56%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.02%	Unkown
HY-132297	PARP1-IN-5	Inhibitor	/	Unkown
HY-151625	PARP-2-IN-3	Inhibitor	/	Unkown
HY-161606	PARP-1/2/7-IN-1	Inhibitor	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-14687	(rac)-Talazoparib	Inhibitor	/	Unkown
HY-168851	PARP1-IN-35	Inhibitor	/	Unkown
HY-105253	PARP-2/1-IN-2	Inhibitor	/	Unkown
HY-170432	PARP1-IN-34	Inhibitor	/	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-145749	PARPYnD	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1	Inhibitor	/	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-169299	TOPOI/PARP-1-IN-2	Inhibitor	/	Unkown
HY-14477	UPF-1035	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Parp2	NCBI	NCBI:10038

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