PARP2 - poly(ADP-ribose) polymerase 2 Gene

Homo sapiens

Also known as ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2

Gene ID: 10038 | Gene type: protein coding

About PARP2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,343,635-20,357,904 (from NCBI)

This gene has 11 transcripts (splice variants), 185 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 14.3), testis (RPKM 13.0) and 25 other tissues.

Summary

This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

PARP2 Products(5)

mRNA	Protein	Name
NM_005484.4	NP_005475.2	poly [ADP-ribose] polymerase 2 isoform 1
XM_005267247.4	XP_005267304.1	poly [ADP-ribose] polymerase 2 isoform X1
XM_047430869.1	XP_047286825.1	poly [ADP-ribose] polymerase 2 isoform X3
XM_017020912.2	XP_016876401.1	poly [ADP-ribose] polymerase 2 isoform X2
NM_001042618.2	NP_001036083.1	poly [ADP-ribose] polymerase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD DNA ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	27471034	GOA
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	30104678	GOA
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	25043379	GOA
enables NAD+-protein-serine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	28190768	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	32939087	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	34108479	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	32939087	GOA
enables poly-ADP-D-ribose binding	IDA IDA: Inferred from direct assay	30104678	GOA
enables poly-ADP-D-ribose modification-dependent protein binding	IDA IDA: Inferred from direct assay	30104678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21812934	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA ADP-ribosylation	IDA IDA: Inferred from direct assay	27471034	GOA
involved in DNA damage response	IDA IDA: Inferred from direct assay	34108479	GOA
involved in DNA repair	IDA IDA: Inferred from direct assay	30104678	GOA
involved in DNA repair-dependent chromatin remodeling	IDA IDA: Inferred from direct assay	32939087	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: Inferred from direct assay	32939087	GOA
involved in protein poly-ADP-ribosylation	IDA IDA: Inferred from direct assay	25043379	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	15615785	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	15615785	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26704974	GOA
is active in site of DNA damage	IDA IDA: Inferred from direct assay	30104678	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	26704974	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP2 Protein Structure

WGR

PARP_reg

PARP

0
100
200
300
400
500
583 a.a.

Protein Preferred Names

Protein Names

poly [ADP-ribose] polymerase 2

ADP-ribosyltransferase (NAD+	poly(ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase diphtheria toxin-like 2	ADPRT-2
DNA ADP-ribosyltransferase PARP2	NAD(+) ADP-ribosyltransferase 2
hPARP-2	poly (ADP-ribose) polymerase family, member 2
poly (ADP-ribosyl) transferase-like 2	poly[ADP-ribose] synthase 2
poly[ADP-ribose] synthetase 2	protein poly-ADP-ribosyltransferase PARP2

PARP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PARP2	Q9UGN5	FKBP3	Homo sapiens	Q00688	Protein Array	21812934
Intra	PARP2	Q9UGN5	FKBP3	Homo sapiens	Q00688	Enzymatic Study	21812934
Intra	PARP2	Q9UGN5	APLF	Homo sapiens	Q8IW19	Protein Array	21812934
Intra	PARP2	Q9UGN5	HMGN2	Homo sapiens	P05204	Protein Array	21812934
Intra	PARP2	Q9UGN5	STAC	Homo sapiens	Q99469	Enzymatic Study	21812934
Intra	PARP2	Q9UGN5	STAC	Homo sapiens	Q99469	Protein Array	21812934

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Fallopian Tube Carcinoma

Fallopian Tube Cancer	Cancer Of The Fallopian Tube
Carcinoma Of Fallopian Tube	Neoplasm Of Fallopian Tube
Fallopian Tube Neoplasms	Fallopian Tube Ca
Fallopian Tube Neoplasm	Malignant Neoplasm Of Uterine Tube
Malignant Tumor Of Fallopian Tube	Malignant Tumour Of Fallopian Tube
Tumor Of The Fallopian Tube	Tumor, Fallopian Tube, Malignant
Malignant Tumor Of Fallopian Tubes	Cancer Of Fallopian Tubes
Malignant Tubal Tumor	Tubal Cancer
Malignant Neoplasm Of Fallopian Tube	Primary Malignant Neoplasm Of Fallopian Tube
Cancer Of The Oviduct

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

Neurodegeneration, Childhood-Onset, Stress-Induced, With Variable Ataxia And Seizures

CONDSIAS

Stress-Induced Childhood-Onset Neurodegeneration With Variable Ataxia And Seizures

Fallopian Tube Disease

Fallopian Tube Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10162	Olaparib	Inhibitor	99.98%	Yes
HY-16106	Talazoparib	Inhibitor	99.89%	Unkown
HY-10619	Niraparib	Inhibitor	99.96%	Yes
HY-10617A	Rucaparib	Inhibitor	99.97%	Unkown
HY-10619B	Niraparib tosylate	Inhibitor	99.99%	Yes
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-10619A	Niraparib hydrochloride	Inhibitor	99.41%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.82%	Yes
HY-10619E	Niraparib tosylate hydrate	Inhibitor	99.97%	Yes
HY-10617C	Rucaparib tartrate	Inhibitor	/	Unkown
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown
HY-10617B	Rucaparib hydrochloride	Inhibitor	/	Unkown
HY-10617D	Rucaparib acetate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-122661	Mefuparib hydrochloride	Inhibitor	98.62%	Phase 4
HY-10129	Veliparib	Inhibitor	99.78%	Phase 3
HY-10130	Veliparib dihydrochloride	Inhibitor	99.98%	Phase 3
HY-132167	Saruparib	Inhibitor	99.76%	Phase 2
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2
HY-137457A	Venadaparib hydrochloride	Inhibitor	/	Phase 2
HY-105303	CEP-9722	Inhibitor	/	Phase 2
HY-13536	AZD-2461	Inhibitor	99.88%	Phase 1
HY-115552	Simmiparib	Inhibitor	99.51%	Phase 1

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-13688A	PJ34	Inhibitor	98.11%	Unkown
HY-13990	NVP-TNKS656	Inhibitor	99.66%	Unkown
HY-13688	PJ34 hydrochloride	Inhibitor	99.91%	Unkown
HY-150207	RBN-3143	Inhibitor	99.24%	Unkown
HY-14478	UPF 1069	Inhibitor	99.10%	Unkown
HY-148566	OUL232	Inhibitor	99.86%	Unkown
HY-100225	ME0328	Inhibitor	99.64%	Unkown
HY-12975	AZ6102	Inhibitor	99.65%	Unkown
HY-137457	Venadaparib	Inhibitor	98.11%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-18954	NMS-P118	Inhibitor	99.54%	Unkown
HY-156419	PARP7-IN-16	Inhibitor	99.91%	Unkown
HY-145584	Nesuparib	Inhibitor	99.43%	Unkown
HY-132297A	PARP1-IN-5 dihydrochloride	Inhibitor	97.56%	Unkown
HY-108632	BYK204165	Inhibitor	98.66%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.89%	Unkown
HY-10614	A-966492	Inhibitor	99.95%	Unkown
HY-156419A	PARP7-IN-16 free base	Inhibitor	99.40%	Unkown
HY-121719	TIQ-A	Inhibitor	99.85%	Unkown
HY-149800	PARP-1-IN-3	Inhibitor	99.30%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-105692	DR2313	Inhibitor	99.66%	Unkown
HY-155993	YCH1899	Inhibitor	99.39%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	98.58%	Unkown
HY-133124	PARP/PI3K-IN-1	Inhibitor	99.43%	Unkown
HY-102035	PARP-2-IN-1	Inhibitor	99.56%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.02%	Unkown
HY-132297	PARP1-IN-5	Inhibitor	/	Unkown
HY-151625	PARP-2-IN-3	Inhibitor	/	Unkown
HY-161606	PARP-1/2/7-IN-1	Inhibitor	/	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-168851	PARP1-IN-35	Inhibitor	/	Unkown
HY-14687	(rac)-Talazoparib	Inhibitor	/	Unkown
HY-105253	PARP-2/1-IN-2	Inhibitor	/	Unkown
HY-170432	PARP1-IN-34	Inhibitor	/	Unkown
HY-158334	NDs-IN-1	Inhibitor	/	Unkown
HY-145749	PARPYnD	Inhibitor	/	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1	Inhibitor	/	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-169299	TOPOI/PARP-1-IN-2	Inhibitor	/	Unkown
HY-14477	UPF-1035	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PARP2	VGNC	VGNC:53577
Felis catus	PARP2	VGNC	VGNC:80893
Rattus norvegicus	PARP2	RGD	RGD:1310568
Macaca mulatta	PARP2	VGNC	VGNC:84417
Canis familiaris	PARP2	VGNC	VGNC:54219
Mus musculus	PARP2	MGD	MGI:1341112
Others	PARP2	NCBI

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