BATF2 - basic leucine zipper ATF-like transcription factor 2 Gene

Homo sapiens

Also known as SARI

Gene ID: 116071 | Gene type: protein coding

About BATF2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,987,945-64,996,971 (from NCBI)

This gene has 5 transcripts (splice variants), 238 orthologues and 8 paralogues. Broad expression in spleen (RPKM 7.0), appendix (RPKM 4.9) and 23 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in defense response to protozoan; myeloid dendritic cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

BATF2 Products(3)

mRNA	Protein	Name
NM_001300807.2	NP_001287736.1	basic leucine zipper transcriptional factor ATF-like 2 isoform 2
NM_001300808.2	NP_001287737.1	basic leucine zipper transcriptional factor ATF-like 2 isoform 3
NM_138456.4	NP_612465.3	basic leucine zipper transcriptional factor ATF-like 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BATF2 Protein Structure

bZIP_1

0
100
200
274 a.a.

Protein Preferred Names

Protein Names

basic leucine zipper transcriptional factor ATF-like 2

B-ATF-2

BATF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BATF2	Q8N1L9	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	BATF2	Q8N1L9	YTHDF1	Homo sapiens	Q9BYJ9	Validated Y2H	32296183
Intra	BATF2	Q8N1L9	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	BATF2	Q8N1L9	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	BATF2	Q8N1L9	PPP1R16A	Homo sapiens	Q96I34	Validated Y2H	32296183
Intra	BATF2	Q8N1L9	MAFF	Homo sapiens	Q9ULX9	FRET	23661758
Intra	BATF2	Q8N1L9	DAZAP2	Homo sapiens	Q15038	Y2H Array	19060904
Intra	BATF2	Q8N1L9	DAZAP2	Homo sapiens	Q15038	Y2H Pooling	19060904
Intra	BATF2	Q8N1L9	CEBPG	Homo sapiens	P53567	FRET	23661758
Intra	BATF2	Q8N1L9	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	BATF2	Q8N1L9	JUNB	Homo sapiens	P17275	Anti Tag CoIP	21988832
Intra	BATF2	Q8N1L9	JUN	Homo sapiens	P05412	FRET	23661758

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01372	BATF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BATF2	VGNC	VGNC:38386
Felis catus	BATF2	VGNC	VGNC:60074
Macaca mulatta	BATF2	VGNC	VGNC:70127
Bos taurus	BATF2	VGNC	VGNC:26426
Rattus norvegicus	BATF2	RGD	RGD:1311481
Mus musculus	BATF2	MGD	MGI:1921731

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