Vcp - valosin-containing protein Gene

Rattus norvegicus

Gene ID: 116643 | Gene type: protein coding

About Vcp

Primary_assembly 5: 57,210,168-57,229,571 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 229 orthologues, 6 paralogues and is associated with 25 phenotypes. Biased expression in Heart (RPKM 1161.1), Muscle (RPKM 181.6) and 9 other tissues.

Summary

Enables ATP hydrolysis activity; adenyl ribonucleotide binding activity; and identical protein binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of synapse organization. Located in cytosol and endoplasmic reticulum. Part of VCP-NPL4-UFD1 AAA ATPase complex and VCP-NSFL1C complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Vcp Products(1)

mRNA	Protein	Name
NM_053864.2	NP_446316.1	transitional endoplasmic reticulum ATPase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IMP IMP: Inferred from mutant phenotype	18332143	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	7806566	RGD
enables ATP binding	IMP IMP: Inferred from mutant phenotype	18332143	RGD
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	7806566	RGD
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	18332143	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	7806566	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	7806566	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9214505	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10811609	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	12847084	RGD
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	7806566	RGD
involved in positive regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	16103111	RGD
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	22105171	RGD
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	22105171	RGD
involved in retrograde protein transport, ER to cytosol	EXP EXP: Inferred from Experiment	12847084	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of VCP-NPL4-UFD1 AAA ATPase complex	EXP EXP: Inferred from Experiment	22232657	RGD
part of VCP-NPL4-UFD1 AAA ATPase complex	IDA IDA: Inferred from direct assay	10811609	RGD
part of VCP-NSFL1C complex	IPI IPI: Inferred from physical interaction	9214505	RGD
located in cytosol	IDA IDA: Inferred from direct assay	9214505	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22105171	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22105171	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Vcp Protein Structure

CDC48

0
200
400
600
806 a.a.

Protein Preferred Names

Protein Names

transitional endoplasmic reticulum ATPase

15S Mg(2+)-ATPase p97 subunit

TER ATPase

Vcp Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Vcp	P46462	Nsfl1c	Rattus norvegicus	O35987	Anti Bait CoIP	9214505
Intra	Vcp	P46462	Nsfl1c	Rattus norvegicus	O35987	GMS	9214505
Intra	Vcp	P46462	Nsfl1c	Rattus norvegicus	O35987	GMS	10811609
Intra	Vcp	P46462	Nsfl1c	Rattus norvegicus	O35987	Competition Binding	20691684

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12861	CB-5083	Inhibitor	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15713	NMS-873	Inhibitor	99.87%	Unkown
HY-123872	MSC1094308	Inhibitor	99.89%	Unkown
HY-128870	Mal-PEG2-VCP-Eribulin		99.82%	Unkown
HY-157508	VCP Activator 1	Activator	99.71%	Unkown
HY-15714	NMS-859	Inhibitor	98.05%	Unkown
HY-124776	NPD8733		99.92%	Unkown
HY-130084	Mal-PEG2-VCP-NB		98.25%	Unkown
HY-138233	KUS121	Modulator	≥98.0%	Unkown
HY-RS15621	VCP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-128871	VCP-Eribulin		/	Unkown
HY-113608	VCP171	Modulator	/	Unkown
HY-139606	VCP/p97 inhibitor-1	Inhibitor	/	Unkown
HY-148122	NW 1028	Inhibitor	/	Unkown
HY-160981	Mal-PEG4-VCP-NB		/	Unkown
HY-160982	Mal-PEG3-VCP-NB		/	Unkown
HY-168325	UP12	Activator	/	Unkown
HY-RS15622	Vcp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15623	Vcp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-168323	UP163	Activator	/	Unkown
HY-168324	UP158	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vcp	NCBI	NCBI:7415

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