Nsfl1c - NSFL1 cofactor Gene

Rattus norvegicus

Also known as p47; XY40

Gene ID: 83809 | Gene type: protein coding

About Nsfl1c

Summary

Enables ATPase binding activity and ubiquitin binding activity. Contributes to phospholipid binding activity. Involved in Golgi organization and membrane fusion. Located in cytosol and spindle pole centrosome. Part of VCP-NSFL1C complex. Orthologous to human NSFL1C (NSFL1 cofactor). [provided by Alliance of Genome Resources, Apr 2022]

Nsfl1c Products(1)

mRNA	Protein	Name
NM_031981.2	NP_114187.1	NSFL1 cofactor p47

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	12146947	RGD
contributes to phospholipid binding	IDA IDA: Inferred from direct assay	12146947	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9214505	RGD
enables ubiquitin binding	IDA IDA: Inferred from direct assay	18775313	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IDA IDA: Inferred from direct assay	12146947	RGD
involved in membrane fusion	IDA IDA: Inferred from direct assay	12146947	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of VCP-NSFL1C complex	IPI IPI: Inferred from physical interaction	9214505	RGD
located in cytosol	IDA IDA: Inferred from direct assay	9214505	RGD
located in spindle pole centrosome	IDA IDA: Inferred from direct assay	23649807	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NSFL1 cofactor p47

NSFL1 (p97) cofactor (p47)	XY body-associated protein XY40
p97 cofactor p47

Nsfl1c Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nsfl1c	O35987	Vcp	Rattus norvegicus	P46462	GMS	16601695
Intra	Nsfl1c	O35987	Vcp	Rattus norvegicus	P46462	Pull Down	20691684
Intra	Nsfl1c	O35987	Vcp	Rattus norvegicus	P46462	EM	16601695
Intra	Nsfl1c	O35987	Vcp	Rattus norvegicus	P46462	Anti Tag CoIP	9214505
Intra	Nsfl1c	O35987	Vcp	Rattus norvegicus	P46462	Anti Bait CoIP	10811609
Intra	Nsfl1c	O35987	Vcp	Rattus norvegicus	P46462	ITC	16601695
Intra	Nsfl1c	O35987	Vcp	Rattus norvegicus	P46462	GMS	9214505
Cross	Nsfl1c	O35987	Vcp	Mus musculus	Q01853	Competition Binding	10811609
Cross	Nsfl1c	O35987	Vcp	Mus musculus	Q01853	Pull Down	20691684

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09592	NSFL1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nsfl1c	NCBI	NCBI:55968

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