2. Gene
  3. FTSJ3 - FtsJ RNA 2'-O-methyltransferase 3 Gene

FTSJ3 - FtsJ RNA 2'-O-methyltransferase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SPB1; EPCS3

Gene ID: 117246 | Gene type: protein coding

About FTSJ3

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,819,433-63,827,663 (from NCBI)

This gene has 16 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 14.7), lymph node (RPKM 12.1) and 25 other tissues.

Summary

Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]

FTSJ3 Products(1)

mRNA Protein Name
NM_017647.4 NP_060117.3 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables RNA 2'-O-methyltransferase activity IDA
IDA: Inferred from direct assay
30626973 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
Biological Process GO Annotation Evidence Reference Source
involved in RNA methylation IDA
IDA: Inferred from direct assay
30626973 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FTSJ3 Protein Structure

FtsJ

FtsJ: FtsJ-like methyltransferase (24 - 200)

DUF3381

DUF3381: Domain of unknown function (DUF3381) (232 - 397)

Spb1_C

Spb1_C: Spb1 C-terminal domain (624 - 841)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 847 a.a.
Protein Preferred Names Protein Names

pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2'-O-ribose RNA methyltransferase SPB1 homolog

FTSJ3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FTSJ3 Q8IY81 SSX2 Homo sapiens Q16385-2
Y2H Prey Pooling
32296183
Intra
FTSJ3 Q8IY81 SSX2 Homo sapiens Q16385-2
Y2H Array
32296183
Intra
FTSJ3 Q8IY81 H1-4 Homo sapiens P10412
Crosslink
30021884
Intra
FTSJ3 Q8IY81 H1-2 Homo sapiens P16403
Crosslink
30021884
Intra
FTSJ3 Q8IY81 OAS3 Homo sapiens Q9Y6K5
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05140 FTSJ3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FTSJ3 VGNC VGNC:41004
Bos taurus FTSJ3 VGNC VGNC:29139
Felis catus FTSJ3 VGNC VGNC:62386
Mus musculus FTSJ3 MGD MGI:1860295
Macaca mulatta FTSJ3 VGNC VGNC:72734
Rattus norvegicus FTSJ3 RGD RGD:1307110